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Effect of 5 weeks of oral acetazolamide on patients with pulmonary vascular disease: A randomized, double-blind, cross-over trial.

Author: AppenzellerP, BerlierC, BlochK E, FurianM, LichtblauM, MayerL, MüllerJ, SaxerS, SchneiderS R, SchwarzE I, SwensonE R, UlrichS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the efficacy of acetazolamide, a carbonic anhydrase inhibitor, in treating patients with pulmonary hypertension (PH) due to pulmonary vascular disease (PVD). While acetazolamide has been shown to attenuate hypoxia-induced PH in animal models, its effectiveness in treating human patients with PVD-related PH remains unknown.
Paper Details　
Original Abstract of the Article :
The carbonic anhydrase inhibitor acetazolamide stimulates ventilation through metabolic acidosis mediated by renal bicarbonate excretion. In animal models, acetazolamide attenuates acute hypoxia-induced pulmonary hypertension (PH), but its efficacy in treating patients with PH due to pulmonary vascu...See full text at original site
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引用元：
https://doi.org/10.1016/j.pulmoe.2022.11.004

データ提供：米国国立医学図書館（NLM）

Acetazolamide: A Potential Treatment for Pulmonary Vascular Disease?

We're delving into the fascinating world of [respiratory medicine] and exploring the potential of [acetazolamide], a [carbonic anhydrase inhibitor], for treating [pulmonary vascular disease (PVD)]. It's like searching for a cure in the vast desert of lung diseases, seeking a way to combat the challenges of [PVD].

Acetazolamide's Effects on Ventilation and Pulmonary Hypertension

The study found that [acetazolamide] stimulates [ventilation] through [metabolic acidosis], but its efficacy in treating [PVD] remains unknown. This is a crucial question, as [PVD] can lead to [pulmonary hypertension], a serious condition that can significantly affect quality of life.

Understanding the Potential of Acetazolamide for Pulmonary Vascular Disease

This study highlights the need for further research to determine the efficacy of [acetazolamide] in treating [PVD]. It's a reminder that the desert of [PVD] research is vast and complex, and we need to continue exploring new approaches to address this challenging condition.

Dr. Camel's Conclusion

This study offers a glimpse into the potential of [acetazolamide] for treating [PVD], but further research is needed to confirm its efficacy and safety. It's a reminder that the desert of lung health research is always evolving, and we need to continue searching for new ways to improve the lives of those affected by [PVD].
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-01-13
Further Info :

Pubmed ID

36639329

DOI: Digital Object Identifier

10.1016/j.pulmoe.2022.11.004

Related Literature

Article Analysis
・Side Effects of acetazolamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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