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Phase 1b study of intravenous coxsackievirus A21 (V937) and ipilimumab for patients with metastatic uveal melanoma.

Author: CohenJustine V, HaqRizwan, LiAnlong, LutzkyJose, RenYixin, SullivanRyan J

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The combination of V937 with ipilimumab showed a manageable safety profile but did not demonstrate meaningful clinical benefit in patients with uveal melanoma and liver metastases.
Paper Details　
Original Abstract of the Article :
PURPOSE: No standard of care therapy exists for patients with metastatic uveal melanoma who are not HLA-A2:01 positive. The phase 1b, open-label CLEVER study (NCT03408587) evaluated V937 in combination with ipilimumab in patients with uveal melanoma. METHODS: Adults with advanced uveal melanoma and...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356892/

データ提供：米国国立医学図書館（NLM）

V937 and Ipilimumab: A New Oasis in Metastatic Uveal Melanoma Treatment?

[Metastatic uveal melanoma] is a challenging cancer to treat. This research investigates the combination of [coxsackievirus A21 (V937)] and [ipilimumab] as a potential therapy for patients with metastatic uveal melanoma who are not [HLA-A2:01 positive].

The researchers conducted a phase 1b clinical trial. Unfortunately, while the combination of V937 and ipilimumab had a manageable safety profile, the results did not show meaningful clinical benefit for patients with liver metastases.

Navigating the Desert of Uveal Melanoma Treatment

The study highlights the ongoing need for research to develop new and effective therapies for metastatic uveal melanoma. It emphasizes the importance of finding treatments that are both safe and effective for patients.

The Journey Continues in Uveal Melanoma Research

This research underscores the importance of continued exploration and innovation in the fight against uveal melanoma. The journey through the desert of cancer research continues, and researchers remain dedicated to finding solutions for patients.

Dr.Camel's Conclusion

This research is like a mirage in the desert of uveal melanoma treatment. While the combination of V937 and ipilimumab did not offer a breakthrough, it provides valuable data for future research and encourages ongoing efforts to develop new and effective therapies for this challenging cancer.

Date :
  1. Date Completed 2023-10-26
  2. Date Revised 2023-10-26
Further Info :

Pubmed ID

36651961

DOI: Digital Object Identifier

PMC10356892

Related Literature

Article Analysis
・Effects of ipilimumab injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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