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Effectiveness of Cefixime for the Treatment of Neisseria gonorrhoeae Infection at 3 Anatomic Sites: A Systematic Review and Meta-Analysis.

Author: BristowClaire C, KlausnerJeffrey D, KojimaNoah, YangKevin J

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study assessed the effectiveness of cefixime in treating Neisseria gonorrhoeae infection at different anatomic sites. A meta-analysis of 20 studies found that cefixime was highly effective in treating urogenital infections but less effective in treating pharyngeal infections. The study recommends further research into cefixime's effectiveness in treating rectal infections and exploring multidose therapy for pharyngeal infections.
Paper Details　
Original Abstract of the Article :
BACKGROUND: To treat Neisseria gonorrhoeae infection, the Centers for Disease Control and Prevention recommends a single oral dose of cefixime as an alternative to injectable ceftriaxone. METHODS: We conducted a systematic review and meta-analysis to describe the effectiveness of cefixime in treati...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/36729626

データ提供：米国国立医学図書館（NLM）

Cefixime: A Reliable Oasis in the Desert of Gonorrhea Treatment?

Gonorrhea is a sexually transmitted infection that requires prompt and effective treatment. This systematic review and meta-analysis delves into the effectiveness of cefixime, an oral antibiotic, for treating gonorrhea infection at various anatomical sites. The researchers analyzed a collection of studies to assess the efficacy and limitations of cefixime as a treatment option.

Cefixime: An Effective Treatment for Urogenital Gonorrhea

The review found that cefixime is highly effective at treating urogenital gonorrhea, with a high success rate in patients receiving a single 400 mg dose. This is like finding a dependable oasis in the desert of gonorrhea treatment, providing a reliable and effective solution for many patients. However, the study also found that cefixime is less effective at treating pharyngeal gonorrhea, suggesting the need for further investigation and potential adjustments to treatment strategies for this specific site.

The Importance of Targeted Treatment

This research highlights the importance of considering the anatomical site of infection when treating gonorrhea. It underscores the need for tailored treatment approaches to ensure optimal outcomes for patients. This study provides valuable insights into the efficacy of cefixime and encourages further research to improve treatment strategies for gonorrhea infection.

Dr. Camel's Conclusion

This research provides a valuable overview of cefixime's effectiveness in treating gonorrhea. While cefixime is a reliable treatment option for urogenital gonorrhea, further research is needed to optimize treatment strategies for pharyngeal infections. We must continue to explore the desert of infectious disease research, seeking new and effective solutions to protect public health.

Date :
  1. Date Completed 2023-02-08
  2. Date Revised 2023-08-23
Further Info :

Pubmed ID

36729626

DOI: Digital Object Identifier

NIHMS1852802

Related Literature

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・Effects of cefixime
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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