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Endothelin Receptor Antagonists in Kidney Disease.

Author: BedardPatricia W, Jacobs-CacháConxita, Llorens-CebriàCarmen, MartosNerea, Martínez-DíazIrene, SolerMaria José, VergaraAnder, ÁlvarezFrancisco J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Endothelin (ET) is elevated in kidney disease and contributes to vasoconstriction, hyperfiltration, and ultimately, glomerular filtration rate (GFR) decline. Endothelin receptor antagonists (ERAs) have been proposed as a therapeutic strategy for kidney disease, as they can reduce proteinuria and fibrosis. While some ERAs have shown promise, adverse events such as edema have limited their use. This review explores current research on ERAs and strategies to minimize their side effects. This includes using ET<sub>A</sub> receptor-specific antagonists, combining ERAs with SGLT2 inhibitors, and developing dual angiotensin-II type 1/endothelin receptor blockers.
Paper Details　
Original Abstract of the Article :
Endothelin (ET) is found to be increased in kidney disease secondary to hyperglycaemia, hypertension, acidosis, and the presence of insulin or proinflammatory cytokines. In this context, ET, via the endothelin receptor type A (ET<sub>A</sub>) activation, causes sustained vasoconstriction of the affe...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965540/

データ提供：米国国立医学図書館（NLM）

Endothelin Receptor Antagonists: A Potential Weapon Against Kidney Disease

This research explores the potential of endothelin receptor antagonists (ERAs) as a therapeutic strategy for managing kidney disease. The authors delve into the role of endothelin (ET) in the progression of kidney disease, explaining how increased ET levels can contribute to vasoconstriction, inflammation, and fibrosis. They review the preclinical and clinical evidence supporting the use of ERAs in reducing proteinuria and slowing the progression of kidney disease.

The study highlights the potential benefits of ERAs in protecting the kidneys, but also acknowledges the challenges associated with their use, including potential adverse effects such as edema. The authors discuss ongoing research exploring the use of ETA receptor-specific antagonists and combinations with other medications, such as sodium-glucose cotransporter 2 inhibitors (SGLT2i), to mitigate these risks and optimize the benefits of ERAs.

A Promising New Treatment

The study suggests that ERAs could become a valuable treatment option for patients with kidney disease. Further research is needed to refine their use and ensure optimal safety and efficacy.

Taking Care of Your Kidneys

Kidney disease is a serious condition. It's important to be aware of the risk factors and to seek medical advice if you experience any symptoms.

Dr. Camel's Conclusion

This research underscores the importance of ongoing research into new and innovative treatments for kidney disease. It's a testament to the resilience of the human body and the tireless efforts of researchers to find solutions for challenging medical conditions. Just as a camel can withstand the harsh conditions of the desert, researchers are constantly striving to protect and preserve the health of the human body.

Date :
  1. Date Completed 2023-03-02
  2. Date Revised 2023-03-02
Further Info :

Pubmed ID

36834836

DOI: Digital Object Identifier

PMC9965540

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Languages

English

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