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ACE2-Inhibitory Effects of Bromelain and Ficin in Colon Cancer Cells.

Author: AllahyariSamaneh, BrückWolfram Manuel, DibazarShaghayegh Pishkhan, FarasatAlireza, PakbinBabak, ShariatifarHanifeh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of bromelain and ficin, enzymes found in pineapple and fig, on human colon cancer cells. Bromelain and ficin were found to decrease the viability and induce apoptosis in these cancer cells. Notably, both enzymes also significantly reduced the expression of ACE2 protein, suggesting a potential role in targeting the angiotensin-converting enzyme pathway.
Paper Details　
Original Abstract of the Article :
<i>Background and Objectives</i>: Bromelain and ficin are aqueous extracts from fruits of <i>Ananas comosus</i> and <i>Ficus carcia</i> plants, used widely for medical applications. Angiotensin-converting enzyme 2 (ACE2) is a homolog of ACE, degrading Ang II to angiotensin 1-7 and decreasing the ce...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962737/

データ提供：米国国立医学図書館（NLM）

Exploring the Potential of Bromelain and Ficin in Colon Cancer Treatment

The fight against cancer is a constant battle, like a never-ending desert trek. This research delves into the potential of bromelain and ficin, two enzymes derived from fruits, as potential cancer treatment agents. The study investigated the effects of these enzymes on colon cancer cells, hoping to discover a new weapon in the fight against this devastating disease.

The researchers found that both bromelain and ficin significantly reduced the viability of human colon cancer cells, inducing apoptosis, or programmed cell death. They also observed a decrease in the expression of ACE2 protein, a target for potential cancer therapy. This discovery is like stumbling upon a hidden spring in the desert, offering a glimmer of hope in the battle against cancer.

A Promising New Frontier in Cancer Treatment: Exploring Natural Solutions

This study suggests that bromelain and ficin could be promising candidates for developing new cancer therapies. The findings encourage further research to explore the therapeutic potential of these natural enzymes and to investigate their mechanisms of action.

Harnessing Nature's Power: A Quest for New Cancer Treatments

This research is a reminder of the vast potential of natural resources in the fight against cancer. By exploring the therapeutic properties of plants and their enzymes, we might discover new and effective treatments that can improve the lives of countless individuals.

Dr. Camel's Conclusion

This research offers a beacon of hope in the ongoing battle against cancer. The study's findings suggest that bromelain and ficin hold promise as potential cancer treatment agents. Further research is needed to fully understand their mechanisms of action and to develop safe and effective therapies. This research reminds us that the desert of scientific exploration is vast and full of potential discoveries that can lead to new breakthroughs in the fight against disease.

Date :
  1. Date Completed 2023-02-28
  2. Date Revised 2023-03-01
Further Info :

Pubmed ID

36837502

DOI: Digital Object Identifier

PMC9962737

Related Literature

Article Analysis
・Effective treatment of bromelain
SNS
PICO Info
in preparation
Languages

English

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