Impact of Concomitant Use of Azoles on Bortezomib-related Adverse Drug Reactions Using JADER.

Author: HaramakiYutaka, ImatohTakuya, MatsumotoTaichi, MigitaKeisuke

Paper Details 
Original Abstract of the Article :
Azoles are widely used for prophylaxis in patients with haematologic malignancies and are well known as selective cytochrome P450 isoenzyme 3A4 inhibitors. Although the interaction between bortezomib and azoles has been reported, most previous studies were case reports or small clinical studies. Hen...See full text at original site
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引用元:
https://doi.org/10.21873/anticanres.16282

データ提供:米国国立医学図書館(NLM)

Azoles and Bortezomib: A Complex Interaction in Cancer Treatment

Cancer treatment is a vast and intricate landscape, with many medications working in tandem to combat the disease. This study explores the interaction between two commonly used drugs: azoles, often prescribed for infection prevention, and bortezomib, a powerful anti-cancer agent. It examines the potential impact of azoles on the side effects associated with bortezomib.

Navigating the Interactions of Cancer Medications

The study delves into the pharmacoepidemiological aspects of this drug interaction, analyzing a large database of adverse drug events. The research suggests that azoles, known for their ability to inhibit specific enzymes, can potentially influence the way bortezomib is metabolized, thereby impacting its effectiveness and side effects.

Informed Decision Making in Cancer Care

This study emphasizes the need for careful consideration of drug interactions when prescribing medications for cancer patients. It highlights the importance of monitoring patients closely for any potential adverse reactions and adjusting treatment plans as needed. The findings underscore the critical role of pharmacists and healthcare providers in ensuring safe and effective cancer treatment.

Dr.Camel's Conclusion

This research, like a seasoned caravan crossing a vast and often unpredictable desert, provides valuable insights into the complex interaction of cancer drugs. It serves as a reminder of the importance of careful planning and vigilance in the ever-evolving landscape of cancer treatment, ensuring the best possible outcomes for patients.
Date :
  1. Date Completed 2023-03-02
  2. Date Revised 2023-03-02
Further Info :

Pubmed ID

36854533

DOI: Digital Object Identifier

10.21873/anticanres.16282

Related Literature

SNS
PICO Info
in preparation
Languages

English

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