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Carbamazepine, venlafaxine, tramadol, and their main metabolites: Toxicological effects on zebrafish embryos and larvae.

Author: CarvalhoA P, GuimarãesL, Oliva-TelesL, RodriguesP

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pharmaceutical compounds and their metabolites can enter aquatic environments through wastewater discharge. This study investigated the toxic effects of metabolites of three common drugs on zebrafish embryos. The findings indicate that these metabolites can cause developmental abnormalities and other adverse effects.
Paper Details　
Original Abstract of the Article :
Pharmaceutical compounds and their metabolites are found in natural and wastewater. However, investigation of their toxic effects on aquatic animals has been neglected, especially for metabolites. This work investigated the effects of the main metabolites of carbamazepine, venlafaxine and tramadol. ...See full text at original site
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引用元：
https://doi.org/10.1016/j.jhazmat.2023.130909

データ提供：米国国立医学図書館（NLM）

The Hidden Dangers of Pharmaceutical Metabolites: A New Frontier in Aquatic Toxicology

The world's waterways are increasingly polluted with pharmaceutical compounds and their metabolites, raising concerns about their impact on aquatic life. This study investigates the toxicity of the main metabolites of three commonly prescribed drugs: carbamazepine, venlafaxine, and tramadol. The research used zebrafish embryos as a model system to assess the effects of these metabolites. The study reveals that these metabolites can cause significant developmental abnormalities in zebrafish embryos, highlighting the potential threat they pose to aquatic ecosystems.

Metabolites: A Silent Threat to Aquatic Life

The study found that the metabolites of carbamazepine, venlafaxine, and tramadol had a significant impact on zebrafish embryos, causing developmental abnormalities. This finding is particularly concerning because metabolites are often overlooked in aquatic toxicity studies. This research underscores the importance of considering the full spectrum of pharmaceutical compounds and their breakdown products when assessing environmental risk.

The Importance of Environmental Awareness: A Call for Action

This research highlights the potential dangers of pharmaceutical contamination in aquatic environments. It underscores the need for comprehensive monitoring and management of pharmaceutical waste to minimize the risks to aquatic life. Think of it as protecting the oasis in the desert, ensuring that the water source remains pure and free from harmful substances.

Dr. Camel's Conclusion

This study serves as a wake-up call, reminding us that the impact of pharmaceuticals extends beyond human health. The presence of drug metabolites in aquatic environments poses a significant threat to aquatic ecosystems. It is essential to address this issue with increased vigilance and responsible waste management practices to protect the delicate balance of our natural world.
Date :
  1. Date Completed 2023-03-06
  2. Date Revised 2023-03-07
Further Info :

Pubmed ID

36860067

DOI: Digital Object Identifier

10.1016/j.jhazmat.2023.130909

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Languages

English

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