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Solriamfetol improves chronic sleep fragmentation-induced increases in sleep propensity and ameliorates explicit memory in male mice.

Author: BadranMohammad, BarrowMax B, GozalDavid, PuechClementine, RunionAlexandra R

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Obstructive sleep apnea (OSA) is a sleep disorder that causes pauses in breathing, leading to sleep fragmentation and daytime sleepiness. This study investigated the effects of two wake-promoting agents, solriamfetol (SOL) and modafinil (MOD), in a mouse model of OSA. Both drugs decreased sleepiness, but only SOL improved memory function. MOD, however, increased anxiety behaviors.
Paper Details　
Original Abstract of the Article :
Obstructive sleep apnea (OSA) is a highly prevalent condition characterized by episodes of partial or complete breath cessation during sleep that induces sleep fragmentation (SF). One of the frequent manifestations of OSA is the presence of excessive daytime sleepiness (EDS) associated with cognitiv...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413435/

データ提供：米国国立医学図書館（NLM）

Solriamfetol: A Hopeful Light for Sleep Fragmentation

Sleep fragmentation, a common symptom of obstructive sleep apnea (OSA), can significantly disrupt sleep quality and lead to daytime sleepiness and cognitive impairment. This study examines the effects of solriamfetol, a wake-promoting agent, on sleep fragmentation in mice.

A Beacon in the Desert of Sleep: Solriamfetol's Benefits

The researchers found that solriamfetol effectively reduced sleep propensity and improved explicit memory in mice with sleep fragmentation, suggesting its potential as a treatment for OSA-related sleep disturbances and cognitive decline. These findings highlight the potential of solriamfetol to improve the lives of individuals struggling with OSA.

Finding a Respite in the Desert: Managing Sleep Fragmentation

This research offers a glimmer of hope for individuals with sleep fragmentation, suggesting that solriamfetol may provide a means to alleviate sleepiness and improve cognitive function. It's like finding a cool spring in a scorching desert, offering a moment of respite from the harsh realities of sleep fragmentation.

Dr.Camel's Conclusion

This study highlights the potential of solriamfetol to improve sleep quality and cognitive function in those with sleep fragmentation. It's like finding a hidden path through the desert, leading to a haven of restful sleep and improved mental clarity.

Date :
  1. Date Completed 2023-05-12
  2. Date Revised 2023-08-12
Further Info :

Pubmed ID

36866452

DOI: Digital Object Identifier

PMC10413435

Related Literature

Article Analysis
・Effects of solriamfetol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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