Potential Anti-Mpox Virus Activity of Atovaquone, Mefloquine, and Molnupiravir, and Their Potential Use as Treatments.

Author: AkazawaDaisuke, AzamAa Haeruman, EbiharaHideki, HishikiTakayuki, IwamiShingo, IwanamiShoya, JeongYong Dam, KataokaMichiyo, KigaKotaro, KimKwang Su, MaedaKen, MifuneJunki, MoritaTakeshi, NakajimaShogo, OhashiHirofumi, OjimaShinjiro, ParkEun-Sil, ParkHyeongki, ShimojimaMasayuki, ShionoyaKaho, SuzukiTadaki, TakahashiYoshimasa, TsuchimotoKana, WatashiKoichi, YoshikawaTomoki

Paper Details 
Original Abstract of the Article :
Mpox virus (MPXV) is a zoonotic orthopoxvirus and caused an outbreak in 2022. Although tecovirimat and brincidofovir are approved as anti-smallpox drugs, their effects in mpox patients have not been well documented. In this study, by a drug repurposing approach, we identified potential drug candidat...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469127/

データ提供:米国国立医学図書館(NLM)

Mpox Virus: Seeking a New Oasis in the Desert of Disease

The emergence of the mpox virus (MPXV) has presented a new challenge in the realm of infectious diseases. While tecovirimat and brincidofovir are approved treatments for smallpox, their effectiveness against mpox remains uncertain. This research employs a drug repurposing approach to identify potential drug candidates for treating mpox, using mathematical modeling to predict their clinical impact. The study highlights atovaquone, mefloquine, and molnupiravir as promising candidates, potentially providing alternative treatment options. This innovative approach is like finding a new water source in a parched desert; it offers a potential solution to a pressing problem.

Exploring New Treatment Avenues for Mpox

The study's findings are significant, as they offer potential alternative treatment options for mpox. The identified drug candidates, atovaquone, mefloquine, and molnupiravir, could provide valuable treatment options, especially considering the uncertainties surrounding the efficacy of existing smallpox treatments against mpox. It's like finding a hidden oasis in the desert; a potentially life-saving resource that was previously unknown.

Navigating the Mpox Threat with Repurposed Drugs

The research provides a foundation for further investigation into the potential use of repurposed drugs for treating mpox. Further clinical trials are needed to confirm the efficacy and safety of these candidates. This ongoing research is like charting a new path through the desert; it requires careful exploration and analysis to ensure its viability and safety. However, this research offers a promising starting point in the fight against mpox and could lead to valuable treatment options for individuals infected with this emerging virus.

Dr. Camel's Conclusion

The emergence of mpox presents a new challenge, but this research offers a ray of hope. The potential use of repurposed drugs represents a promising avenue for treatment, potentially providing a much-needed oasis in the desert of mpox. However, continued research and clinical trials are crucial to confirm their effectiveness and safety. This journey through the desert of disease requires patience, persistence, and a willingness to explore new possibilities.

Date :
  1. Date Completed 2023-12-14
  2. Date Revised 2023-12-14
Further Info :

Pubmed ID

36892247

DOI: Digital Object Identifier

PMC10469127

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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