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Oxazolidinone: A promising scaffold for the development of antibacterial drugs.

Author: BaiYi-Ru, LiuHong-Min, ShenDan-Dan, SunChong, WangSai-Qi, YuanShuo, ZhangMiao, ZhouLi, ZhouTian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review summarizes oxazolidinone-based antibiotics, which are effective against Gram-positive bacteria. It focuses on their structural optimizations, development strategies, and structure-activity relationships to guide the development of new antibiotics with higher potency and fewer side effects.
Paper Details　
Original Abstract of the Article :
Due to the long-term and widespread use of antibiotics in clinic, the problem of bacterial resistance is increasingly serious, and the development of new drugs to treat drug-resistant bacteria has gradually become the mainstream direction of antibiotic research. The oxazolidinone-containing drugs li...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejmech.2023.115239

データ提供：米国国立医学図書館（NLM）

Oxazolidinone: A Promising Scaffold for Antibacterial Drug Development

The rise of bacterial resistance poses a significant threat to global health, demanding the development of new antibacterial agents. This research explores the potential of oxazolidinone as a promising scaffold for the development of novel antibacterial drugs. The study highlights the success of existing oxazolidinone-based antibiotics, such as linezolid, tedizolid phosphate, and contezolid, in treating various Gram-positive bacterial infections. Furthermore, the research delves into the structural optimization strategies and structure-activity relationships of oxazolidinone-containing antibiotics, aiming to guide the development of new agents with enhanced potency and reduced side effects. This research underscores the potential of oxazolidinone as a valuable scaffold for addressing the urgent need for new antibacterial agents.

Addressing the Urgent Need for New Antibiotics

This research highlights the potential of oxazolidinone as a valuable scaffold for addressing the urgent need for new antibacterial agents. The study emphasizes the success of existing oxazolidinone-based antibiotics in treating Gram-positive bacterial infections and explores strategies for developing new agents with enhanced potency and reduced side effects. This research provides valuable insights into the design and development of novel antibacterial drugs, potentially contributing to the fight against antibiotic resistance.

Navigating the Desert of Antibiotic Resistance

Antibiotic resistance is a growing threat, like a looming sandstorm in the desert of global health. This research offers a potential oasis of hope by exploring the promise of oxazolidinone as a scaffold for developing new antibacterial drugs. By understanding the structure-activity relationships of oxazolidinone-based antibiotics, researchers can navigate the challenging landscape of antibiotic resistance and develop novel agents with enhanced potency and reduced side effects.

Dr.Camel's Conclusion

This research, like a camel traversing a vast desert in search of a water source, explores the potential of oxazolidinone as a promising scaffold for developing new antibacterial drugs. By understanding the structure-activity relationships of oxazolidinone-based antibiotics, researchers can navigate the challenging landscape of antibiotic resistance and develop novel agents with enhanced potency and reduced side effects.

Date :
  1. Date Completed 2023-03-15
  2. Date Revised 2023-03-15
Further Info :

Pubmed ID

36893700

DOI: Digital Object Identifier

10.1016/j.ejmech.2023.115239

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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