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New Dual Endothelin Receptor Antagonist Aprocitentan in Hypertension: A Systematic Review and Meta-Analysis.

Author: DharmarajanLekshmi, GrewalDaisy, HussainAftab, KhamoshMadina, MahfoozKamran, NajeedSyed, OngKenneth, TunHan Naung, VasavadaAdvait

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Aprocitentan is a new drug for resistant hypertension. This study found that it lowered blood pressure in patients with hypertension, even with a dose exceeding 25mg, but its long-term efficacy and safety need further investigation.
Paper Details　
Original Abstract of the Article :
Hypertension is one of the most common disorders encountered, yet pharmacotherapy for resistant hypertension has limited effective options. Aprocitentan is postulated to be a novel antihypertensive. The main goal was to determine the effect of aprocitentan on blood pressure among patients with hyper...See full text at original site
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引用元：
https://doi.org/10.1016/j.cpcardiol.2023.101686

データ提供：米国国立医学図書館（NLM）

A New Hope for Resistant Hypertension: Aprocitentan

This systematic review and meta-analysis examines the potential of aprocitentan, a novel dual endothelin receptor antagonist, for the treatment of hypertension, particularly resistant hypertension. It's like exploring a new desert oasis, seeking a solution to the challenges of managing high blood pressure. Researchers reviewed multiple studies to assess the effectiveness of aprocitentan in lowering blood pressure. The review provides a comprehensive overview of the current evidence on aprocitentan, highlighting its potential as a promising new treatment option for resistant hypertension.

A New Weapon Against High Blood Pressure

This research offers hope for individuals struggling with resistant hypertension. It suggests that aprocitentan could be a valuable addition to the existing arsenal of treatments for high blood pressure. It's like finding a new oasis in the desert of hypertension management, offering a source of relief and a potential path to better health.

A Promise for a Healthier Future

This review suggests that aprocitentan could be a promising new treatment option for resistant hypertension, potentially offering a better chance for individuals to manage their blood pressure and achieve better health outcomes. It's like finding a new route through the desert of hypertension, offering a more effective and potentially safer way to navigate this challenging condition.

Dr.Camel's Conclusion

This review highlights the potential of aprocitentan as a promising new treatment for resistant hypertension. It underscores the importance of ongoing research and development to identify effective therapies for high blood pressure. It's like navigating a vast and complex desert landscape, where finding the right path to health requires constant exploration and innovation.
Date :
  1. Date Completed 2023-05-26
  2. Date Revised 2023-05-26
Further Info :

Pubmed ID

36893968

DOI: Digital Object Identifier

10.1016/j.cpcardiol.2023.101686

Related Literature

Article Analysis
・Effects of aprocitentan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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