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Ocular adverse events associated with BRAF and MEK inhibitor combination therapy: a pharmacovigilance disproportionality analysis of the FDA adverse event reporting system.

Author: DuQiong, GuoZihan, HuangShuohan, LiuJiyong, SheYoujun, WangMengmeng, YeXuan, ZhaiQing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study analyzed the United States Food and Drug Administration Adverse Event Reporting System (FAERS) data to detect ocular adverse events (oAEs) associated with BRAF and MEK inhibitor combination therapies. The study identified several oAEs, including some not previously reported. Differences in oAE profiles were observed among different combination therapies. Further research is needed to quantify these oAEs.
Paper Details　
Original Abstract of the Article :
BACKGROUND: BRAF and MEK inhibitor combination therapy have significantly improved the outcome of several BRAF-mutation tumors, but it also confers the risk of drug-induced ocular adverse events (oAEs). However, very few studies focused on this risk. METHODS: The United States Food and Drug Adminis...See full text at original site
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引用元：
https://doi.org/10.1080/14740338.2023.2189235

データ提供：米国国立医学図書館（NLM）

Navigating the Side Effects of BRAF and MEK Inhibitors: A Pharmacovigilance Study

Cancer treatments, like navigating a treacherous desert, can come with unexpected side effects. This research explores the potential ocular adverse events (oAEs) associated with BRAF and MEK inhibitor combination therapy. The study aimed to identify and analyze oAEs reported in the FDA Adverse Event Reporting System (FAERS), seeking to understand the risks associated with these therapies.

The researchers analyzed FAERS data, discovering a range of oAEs associated with three BRAF and MEK inhibitor combination therapies. They found that certain oAEs were more common with specific combinations. This is like uncovering different paths through the desert, each with its own unique challenges and dangers.

Understanding the Risks of Cancer Treatment: A Journey Through the Desert

This study highlights the importance of understanding the potential side effects of cancer treatments. The findings emphasize the need for careful monitoring and early intervention to manage oAEs and to ensure the safety of patients receiving these therapies.

Balancing Benefits and Risks: A Crucial Decision

This study underscores the importance of weighing the benefits and risks of cancer treatments. While BRAF and MEK inhibitors offer hope for patients with BRAF-mutation tumors, it's crucial to be aware of the potential side effects. This research serves as a reminder that making informed decisions about cancer treatment is a complex process, requiring careful consideration of all factors.

Dr. Camel's Conclusion

This research provides valuable insights into the potential ocular adverse events associated with BRAF and MEK inhibitor combination therapy. The findings emphasize the importance of careful monitoring and early intervention to manage these side effects. It is crucial to weigh the benefits and risks of these therapies, ensuring that patients receive the best possible care.

Date :
  1. Date Completed 2023-03-16
  2. Date Revised 2023-03-16
Further Info :

Pubmed ID

36896641

DOI: Digital Object Identifier

10.1080/14740338.2023.2189235

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Languages

English

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