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Potential Anti-SARS-CoV-2 Prodrugs Activated by Phosphorylation and Their Role in the Aged Population.

Author: BalarPankti C, ChavdaVivek P, SolankiHetvi K, TeliDivya, VaghelaDixa, VaishnavAkta, VoraLalitkumar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article discusses the use of prodrugs for COVID-19 treatment, particularly in the aged population. It highlights prodrugs like remdesivir, molnupiravir, favipiravir, and 2-deoxy-D-glucose (2-DG) and their potential benefits and challenges.
Paper Details　
Original Abstract of the Article :
The COVID-19 pandemic has flared across every part of the globe and affected populations from different age groups differently. People aged from 40 to 80 years or older are at an increased risk of morbidity and mortality due to COVID-19. Therefore, there is an urgent requirement to develop therapeut...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004871/

データ提供：米国国立医学図書館（NLM）

Fighting COVID-19 in the Desert of Aging: Prodrugs Offer a Potential Oasis

The COVID-19 pandemic has swept across the globe, leaving behind a trail of devastation, particularly among the elderly. This research seeks to find a new oasis of hope in the fight against COVID-19, focusing on the development of prodrugs specifically designed to combat the virus in the aging population. The authors explore the potential of prodrugs, which are activated by phosphorylation, to effectively deliver antiviral agents to the sites where they are needed most. They discuss various prodrugs currently under investigation, including remdesivir, molnupiravir, favipiravir, and 2-deoxy-D-glucose (2-DG), highlighting their potential for mitigating COVID-19 risks in the elderly. The research underscores the urgency of developing effective therapies to protect the most vulnerable populations.

Prodrugs: A Beacon of Hope in the COVID-19 Desert

This research explores the potential of prodrugs as a promising strategy for combating COVID-19, especially in the aging population. Prodrugs offer a unique advantage by enhancing drug delivery and reducing toxicity, potentially providing a more effective and safer treatment approach. The research highlights the importance of developing targeted therapies to meet the specific needs of vulnerable populations.

Navigating the Desert of Aging and COVID-19

This research offers a glimmer of hope for the aging population battling COVID-19. Prodrugs, by their nature of enhanced drug delivery and reduced toxicity, hold the potential to improve treatment outcomes and mitigate the risks associated with this devastating virus. The research underscores the need for continued investment in developing therapies specifically tailored to meet the needs of the elderly, ensuring they receive the care and protection they deserve.

Dr. Camel's Conclusion

This research illuminates the potential of prodrugs in combating COVID-19, especially in the aging population. By focusing on targeted drug delivery and reducing toxicity, prodrugs offer a promising avenue for developing effective therapies. The desert of aging may present unique challenges, but this research provides a roadmap for navigating the treacherous terrain and finding a path towards a brighter future.

Date :
  1. Date Completed 2023-03-14
  2. Date Revised 2023-03-14
Further Info :

Pubmed ID

36903575

DOI: Digital Object Identifier

PMC10004871

Related Literature

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・Effects of molnupiravir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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