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Effect of a slow release preparation of levodopa on Parkinson's disease in combination with a peripheral decarboxylase inhibitor.

Author: HokkanenE, MyllyläV V, SaarinenA, TokolaO

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A slow release levodopa preparation helped to reduce fluctuations in plasma levodopa levels and improve parkinsonian signs in patients whose earlier therapy had proved inadequate.
Paper Details　
Original Abstract of the Article :
Plasma concentrations of levodopa were determined after therapeutic oral levodopa-carbidopa doses. The wide fluctuations observed in plasma levodopa levels could be considerably reduced by the addition of a slow release levodopa preparation. This kind of combination medication was given to 15 parkin...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0404.1978.tb02898.x

データ提供：米国国立医学図書館（NLM）

Parkinson's Disease: Navigating the Shifting Sands

Parkinson's disease, like a desert landscape that constantly shifts, presents a unique set of challenges for individuals seeking relief. This study focuses on the effectiveness of a slow-release levodopa preparation in combination with a peripheral decarboxylase inhibitor for managing Parkinson's symptoms. Researchers aimed to improve the delivery of levodopa, a crucial medication for Parkinson's, by reducing fluctuations in plasma levels, creating a more stable therapeutic effect.

Finding Balance: Optimizing Levodopa Therapy

Imagine a desert traveler trying to navigate a shifting sand dune. The slow-release levodopa preparation helps to smooth out the delivery of the medication, minimizing the unpredictable fluctuations in plasma levels. This approach aims to provide a more consistent therapeutic effect, potentially enhancing the management of Parkinson's symptoms.

Easing the Journey: Managing Parkinson's

This research highlights the potential for improved medication strategies to enhance the quality of life for individuals living with Parkinson's disease. Just as a traveler prepares for a desert journey, individuals with Parkinson's can work with their healthcare providers to optimize medication regimens, potentially finding a more stable and manageable path through their condition.

Dr.Camel's Conclusion

Parkinson's disease, like a shifting desert landscape, presents ongoing challenges. This study explores the potential benefits of a slow-release levodopa preparation, offering a more consistent therapeutic approach. The research emphasizes the importance of finding the right balance in medication management, providing hope for individuals seeking to navigate the complexities of this condition.

Date :
  1. Date Completed 1979-04-25
  2. Date Revised 2019-08-14
Further Info :

Pubmed ID

369277

DOI: Digital Object Identifier

10.1111/j.1600-0404.1978.tb02898.x

Related Literature

Article Analysis
・Side Effects of levodopa and carbidopa
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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