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Office-Based Photodynamic Therapy Using Locally Applied 5-aminolevulinic Acid and 635 nm Laser for Laryngeal Leukoplakia.

Author: HouQian, JiangJack J, LiGelin, RenHui, SilvermanMatthew, ZhangChi, ZhongJingting

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This retrospective cohort study investigated the efficacy of in-office photodynamic therapy (PDT) using local 5-aminolevulinic acid (ALA) and a 635 nm diode laser for treating laryngeal leukoplakia. The study found a 96.875% response rate, with 81.25% complete responses. PDT selectively eliminated leukoplakia without affecting lamina propria, and voice quality improved significantly. These findings suggest that office-based PDT is a safe and effective treatment for laryngeal leukoplakia.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Photodynamic therapy (PDT) is a minimally invasive method with strong tissue selectivity and nonthermal effects. We aim to investigate the efficacy of an in-office method utilizing PDT with local application of 5-aminolevulinic acid (ALA) and 635 nm diode laser for treating laryngeal leuk...See full text at original site
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引用元：
https://doi.org/10.1002/ohn.169

データ提供：米国国立医学図書館（NLM）

Photodynamic Therapy: A Promising Treatment for Laryngeal Leukoplakia

The field of otorhinolaryngology focuses on the diagnosis and treatment of conditions affecting the ears, nose, and throat. Laryngeal leukoplakia is a precancerous condition that can occur in the larynx, the voice box. This study investigates the effectiveness of photodynamic therapy (PDT), a minimally invasive treatment, for laryngeal leukoplakia. Researchers conducted a retrospective cohort study to analyze the outcomes of PDT using locally applied 5-aminolevulinic acid (ALA) and a 635 nm diode laser in patients with laryngeal leukoplakia. Their findings suggest that PDT is an effective and safe treatment option for laryngeal leukoplakia, with a high response rate and minimal side effects.

Photodynamic Therapy: A Targeted Approach to Treating Laryngeal Leukoplakia

This research demonstrates that PDT is a promising treatment for laryngeal leukoplakia. The study found that PDT effectively eliminated the leukoplakia lesions in the majority of patients, with minimal damage to surrounding healthy tissues. PDT offers a minimally invasive alternative to surgery for treating laryngeal leukoplakia.

Protecting Your Voice: Recognizing and Managing Laryngeal Conditions

Individuals who experience changes in their voice, such as hoarseness or difficulty speaking, should consult with a healthcare professional. Early diagnosis and treatment can help prevent more serious complications.

Dr. Camel's Conclusion

This study is like a ray of light in the desert of laryngeal leukoplakia treatments, offering a new and effective option for patients. The research highlights the potential of PDT as a minimally invasive and safe treatment for this precancerous condition.

Date :
  1. Date Completed 2023-03-28
  2. Date Revised 2023-04-22
Further Info :

Pubmed ID

36939544

DOI: Digital Object Identifier

10.1002/ohn.169

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Languages

English

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