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Does Adjunction of Autologous Osteoblastic Cells Improve the Results of Core Decompression in Early-stage Femoral Head Osteonecrosis? A Double-blind, Randomized Trial.

Author: CarronPhilippe, DavisEdward T, DubranaFrederic, GangjiValérie, GodeauxOlivier, GüntherKlaus-Peter, JayankuraMarc, RondiaJean, SeefriedLothar, SonnetWendy, ThomasThierry, Vande BergBruno, Winnock de GravePhilip

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study aims to confirm the efficacy of core decompression of the femoral head combined with cell therapies in patients with early-stage ONFH.
Paper Details　
Original Abstract of the Article :
Osteonecrosis of the femoral head (ONFH) is a disabling disease that can ultimately progress to collapse of the femoral head, often resulting in THA. Core decompression of the femoral head combined with cell therapies have shown beneficial effects in previous clinical studies in patients with early-...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344543/

データ提供：米国国立医学図書館（NLM）

Core Decompression: A Double-Blind Randomized Trial for Femoral Head Osteonecrosis

This article presents the results of a double-blind, randomized trial investigating the effectiveness of [core decompression] combined with [autologous osteoblastic cells] in treating [early-stage femoral head osteonecrosis (ONFH)]. The authors aimed to determine whether the addition of cells improves the outcomes of core decompression in patients with ARCO Stage I and II ONFH. While previous studies have suggested potential benefits of cell therapies, the current trial did not find conclusive evidence to support the efficacy of this approach.

Exploring the Potential of Cell Therapies for Osteonecrosis

This article delves into the promising but still evolving field of cell therapies for ONFH. While the current trial did not find conclusive evidence to support the efficacy of adding autologous osteoblastic cells to core decompression, the authors acknowledge the need for further research to fully understand the potential of these therapies. It's like exploring a vast and uncharted desert, where each expedition yields new insights and potentially promising discoveries.

Navigating the Complexities of Osteonecrosis Treatment

This research highlights the ongoing search for effective treatments for ONFH, a debilitating condition that can lead to joint collapse and pain. While the current trial did not find conclusive evidence to support the efficacy of adding autologous osteoblastic cells to core decompression, the authors acknowledge the need for further research to explore the potential of these therapies. It's like navigating a challenging desert terrain, where finding the right path requires careful exploration and ongoing research.

Dr. Camel's Conclusion

This double-blind randomized trial investigated the effectiveness of core decompression combined with autologous osteoblastic cells in treating early-stage femoral head osteonecrosis. While the findings did not provide conclusive evidence to support the efficacy of this approach, the authors acknowledge the need for further research to fully understand the potential of cell therapies for ONFH. It's like exploring a vast and uncharted desert, where each expedition yields new insights and potentially promising discoveries.
Date :
  1. Date Completed 2023-07-24
  2. Date Revised 2023-07-25
Further Info :

Pubmed ID

36961220

DOI: Digital Object Identifier

PMC10344543

Related Literature

Article Analysis
・Effective treatment of osteonecrosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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