Paper Details

  1. Home
  2. Paper Details

Structural Characterization and Anti-inflammatory Activities of Anticomplementary Polysaccharides from Rhododendron principis.

Author: , BaoWei-Lian, ChenDao-Feng, HongZhou, LiuYang, LuYan, ZhangJie, ZhaoZhi-Zhi, ZhouLi-Shuang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the anti-inflammatory effects of *Rhododendron principis* crude polysaccharides on acute lung injury induced by lipopolysaccharide in mice. The study found that the crude polysaccharides significantly decreased the levels of TNF-α and interleukin-6 in both serum and bronchoalveolar lavage fluid. A heteropolysaccharide, ZNDHP, was isolated from the crude polysaccharides and found to exhibit potent anti-inflammatory activity by inhibiting the secretion of nitric oxide, TNF-α, interleukin-6, and interleukin-1β in lipopolysaccharide-treated RAW 264.7 cells.
Paper Details　
Original Abstract of the Article :
<i>Rhododendron principis</i> leaves have been used as "Dama", a Traditional Tibetan Medicine for treating inflammatory diseases. <i>R.&#160;principis</i> crude polysaccharides with anticomplementary activity demonstrated promising anti-inflammatory effects on acute lung injury induced by lipopolys...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1055/a-2063-5595

データ提供：米国国立医学図書館（NLM）

Rhododendron principis: A Hidden Oasis of Anti-inflammatory Power

The [Traditional Tibetan Medicine] has a long history of using natural remedies to treat various ailments. This research explores the [anti-inflammatory properties] of [Rhododendron principis], a plant traditionally used to treat inflammatory diseases. The authors investigated the [anticomplementary and anti-inflammatory activities] of [crude polysaccharides] extracted from R. principis leaves. They discovered that [these polysaccharides] exhibited significant anti-inflammatory effects in a mouse model of [lipopolysaccharide (LPS)-induced acute lung injury]. Furthermore, they identified a specific [heteropolysaccharide, ZNDHP], which was responsible for these potent activities.

A Powerful Oasis: ZNDHP

The study revealed that [ZNDHP] possesses a unique [branched structure] and exhibits [remarkable anti-inflammatory effects]. It significantly reduced the levels of [inflammatory markers] like TNF-α and IL-6 in both serum and blood, demonstrating its potential as a therapeutic agent. This discovery is like finding a hidden oasis in the desert of inflammatory diseases, offering a natural and effective solution.

Navigating the Desert of Inflammation

This research highlights the [potential of natural remedies] to address inflammatory conditions. It encourages further investigation into the [medicinal properties] of plants like R. principis, exploring their therapeutic potential for various inflammatory diseases. It's like venturing into a desert rich with hidden treasures, where careful exploration can reveal valuable resources for healing and well-being.

Dr. Camel's Conclusion

This study unveils the remarkable anti-inflammatory potential of Rhododendron principis, highlighting the therapeutic value of traditional medicinal practices. The discovery of ZNDHP, a potent heteropolysaccharide with significant anti-inflammatory activity, offers a promising avenue for the development of natural therapies for inflammatory diseases. It's a reminder that even in the vast and often challenging desert of medicine, hidden oases of healing and restoration can be found.

Date :
  1. Date Completed 2023-08-10
  2. Date Revised 2023-08-10
Further Info :

Pubmed ID

36977490

DOI: Digital Object Identifier

10.1055/a-2063-5595

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.