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Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation.

Author: DonthiMahipal Reddy, DubeySunil Kumar, SahaRanendra Narayan, SinghviGautam

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Dasatinib (DTB) is a tyrosine kinase inhibitor used to treat rheumatoid arthritis (RA). This study developed a topical nano-emulgel formulation of DTB to reduce systemic side effects. The QbD approach was used to optimize the emulgel, resulting in a formulation with sustained drug release, improved skin permeation, and significant reduction in paw swelling in an animal model of RA.
Paper Details　
Original Abstract of the Article :
The current study aimed to develop a topical emulgel of dasatinib (DTB) for rheumatoid arthritis (RA) treatment to reduce systemic side effects. The quality by design (QbD) approach was employed to optimize DTB-loaded nano-emulgel using a central composite design (CCD). Emulgel was prepared using th...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052882/

データ提供：米国国立医学図書館（NLM）

Dasatinib-Loaded Emulgel: A Potential New Treatment for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can significantly impact quality of life. This study explores the potential of a topical emulgel formulation containing dasatinib, a drug typically used for leukemia, as a new treatment option for RA. The researchers employed a quality-by-design approach to optimize the emulgel formulation, resulting in a product with sustained release properties, excellent skin permeation, and promising in vitro and in vivo efficacy.

A New Approach for Treating Rheumatoid Arthritis

The study suggests that a topical dasatinib emulgel could provide a targeted and sustained delivery of the drug directly to the affected joints, potentially reducing systemic side effects and improving therapeutic efficacy. This approach holds promise for improving the management of RA, offering a new alternative to traditional systemic therapies.

Managing Rheumatoid Arthritis: A Holistic Approach

RA is a complex condition, and managing it effectively often requires a multifaceted approach. The study highlights the potential of topical therapies in reducing inflammation and pain, but it is important to remember that treatment should be tailored to the individual patient and may involve a combination of therapies, including lifestyle modifications, physical therapy, and other medications. Consulting with a healthcare professional is essential for developing a personalized management plan.

Dr.Camel's Conclusion

This study presents a promising new approach to the treatment of rheumatoid arthritis. The development of a topical dasatinib emulgel with sustained release properties could revolutionize the management of this chronic condition. While further clinical trials are needed to confirm its efficacy and safety, this research offers hope for a new era in RA treatment.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-03-31
Further Info :

Pubmed ID

36986597

DOI: Digital Object Identifier

PMC10052882

Related Literature

Article Analysis
・Side Effects of dasatinib
SNS
PICO Info
in preparation
Languages

English

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