Analgesic Effect of Buprenorphine for Chronic Noncancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Author: ChanTak Hon, ChanTimmy Chi Wing, CheungChi Wai, HoHung Chak, WangFengfeng, WongStanley Sau Ching

Paper Details 
Original Abstract of the Article :
Buprenorphine is a partial agonist at the µ-opioid receptor and an antagonist at the delta and kappa opioid receptors. It has high affinity and low intrinsic activity at the µ-opioid receptor. Buprenorphine demonstrates no ceiling effect for clinical analgesia, but demonstrates this for respiratory ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/36988663

データ提供:米国国立医学図書館(NLM)

Buprenorphine for Chronic Pain: A Powerful Pain Relief

In the vast landscape of pain management, scientists are constantly exploring new and effective treatments. This study focuses on buprenorphine, a medication with unique properties that show promise for managing chronic pain. The study examines the analgesic efficacy of buprenorphine, a partial opioid agonist, and its potential advantages over traditional opioids.

The researchers conducted a systematic review and meta-analysis to analyze the evidence supporting the use of buprenorphine for chronic non-cancer pain. Their findings suggest that buprenorphine demonstrates high affinity for the µ-opioid receptor, leading to effective pain relief. Notably, buprenorphine exhibits a ceiling effect for respiratory depression and euphoria, potentially leading to a more favorable safety profile compared to full opioid agonists.

Buprenorphine: A Promising Pain Relief Option

The findings of this research suggest that buprenorphine may be a promising treatment option for chronic pain, providing effective analgesia while minimizing adverse effects. This information empowers clinicians to make informed decisions about pain management strategies and explore alternative options for patients seeking relief from chronic pain.

Navigating Buprenorphine: A Balanced Approach

The study's findings emphasize the importance of considering buprenorphine as a potential treatment option for patients with chronic pain. However, it's crucial to acknowledge that buprenorphine, like any medication, can have side effects. It's essential for patients to engage in open communication with their healthcare providers to determine the most appropriate pain management approach and to monitor their response to treatment.

Dr. Camel's Conclusion

This research provides valuable insights into the analgesic efficacy of buprenorphine, highlighting its potential as a safe and effective treatment option for chronic pain. The study's findings encourage further investigation of buprenorphine's role in pain management, potentially leading to improved treatment outcomes for patients suffering from chronic pain.

Date :
  1. Date Completed 2023-06-19
  2. Date Revised 2023-11-19
Further Info :

Pubmed ID

36988663

DOI: Digital Object Identifier

00000539-202307000-00006

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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