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Effects of tizanidine, a centrally acting muscle relaxant, on motor systems.

Author: FukudaH, KatoF, KatoK, MatsumotoK, MiyamotoM, MoriT, NakamuraT, OkaJ, OnoH

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tizanidine effectively reduced muscle rigidity and spasticity by depressing the gamma-system and spinal reflexes. The drug's mechanism of action was different from other centrally acting muscle relaxants, such as mephenesin and benzodiazepines.
Paper Details　
Original Abstract of the Article :
Effects of tizanidine were studied with special reference to the effect on motor systems. The drug effectively reduced the intercollicular decerebrate rigidity and gamma-activity indirectly recorded from muscle spindle afferent discharges without showing the direct inhibitory effect on muscle spindl...See full text at original site
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引用元：
https://doi.org/10.1016/0306-3623(86)90130-8

データ提供：米国国立医学図書館（NLM）

Tizanidine: A Centrally Acting Muscle Relaxant

Muscle relaxants are commonly used to alleviate muscle spasms and pain. This study explores the effects of tizanidine, a centrally acting muscle relaxant, on motor systems.

Tizanidine: A Multifaceted Approach to Muscle Relaxation

The study found that tizanidine effectively reduced muscle rigidity, inhibited spinal reflexes, and depressed gamma-activity, a key component of the nervous system's control of muscle tone. These findings suggest that tizanidine works by targeting multiple mechanisms within the nervous system, a complex process akin to a camel navigating a challenging desert landscape.

Understanding Muscle Relaxants: Choosing the Right Treatment

This research highlights the importance of understanding the mechanisms of action of different muscle relaxants to choose the most effective treatment for each patient. Tizanidine's ability to target multiple pathways makes it a potentially valuable option for managing muscle spasms and pain.

Dr. Camel's Conclusion

This study provides valuable insights into the mechanisms of action of tizanidine, a promising muscle relaxant. The research underscores the importance of choosing the right muscle relaxant for each patient, a decision that should be made in consultation with a healthcare professional.

Date :
  1. Date Completed 1986-06-02
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

3699439

DOI: Digital Object Identifier

10.1016/0306-3623(86)90130-8

Related Literature

Article Analysis
・Effects of tizanidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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