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Lipid Prodrug Nanoassemblies via Dynamic Covalent Boronates.

Author: DingYuxun, HuXiaowen, HuangRong, LiYuanfeng, LiuYong, PiaoYinzi, ShiLinqi, SunHui, XieLingping, YanXiaojian

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study introduces a novel method to create lipid prodrug nanoassemblies (LPNAs) using dynamic covalent boronate chemistry. The resulting LPNAs possess unique properties like dynamic drug loading, charge reversal, and targeted release, demonstrating enhanced therapeutic efficacy compared to free drugs in vitro and in vivo.
Paper Details　
Original Abstract of the Article :
Prodrug nanoassemblies combine the advantages of prodrug and nanomedicines, offering great potential in targeting the lesion sites and specific on-demand drug release, maximizing the therapeutic performance while minimizing their side effects. However, there is still lacking a facile pathway to prep...See full text at original site
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引用元：
https://doi.org/10.1021/acsnano.2c12233

データ提供：米国国立医学図書館（NLM）

Lipid Prodrug Nanoassemblies via Dynamic Covalent Boronates

In the ever-expanding desert of nanomedicine research, scientists are constantly seeking new ways to deliver drugs effectively and safely. This research explores the development of lipid prodrug nanoassemblies (LPNAs) using dynamic covalent boronates. This is like finding a new type of camel that can carry valuable resources through a challenging desert landscape.

LPNAs for Targeted Drug Delivery

The researchers have developed a novel method for preparing LPNAs that allows for drug loading in a dynamic covalent manner, charge reversal in an acidic microenvironment, and specific drug release at acidic or oxidative microenvironments. This is like having a camel that can adapt to different environments and release its precious cargo at the right time and place. The researchers tested the efficacy of this approach with three model drugs, demonstrating its potential for targeted drug delivery.

Health Benefits and Lifestyle Implications

This research holds promise for the development of more effective and targeted drug delivery systems. It's like discovering a new oasis in the desert, providing a safer and more efficient way to transport essential resources. This approach could lead to improved treatment outcomes and reduced side effects for patients.

Dr. Camel's Conclusion

This research presents an exciting new approach for designing and developing lipid prodrug nanoassemblies. It's like finding a new breed of camel that can navigate the challenges of drug delivery with grace and efficiency. This research has the potential to revolutionize drug delivery and improve patient care.

Date :
  1. Date Completed 2023-04-12
  2. Date Revised 2023-04-17
Further Info :

Pubmed ID

36999933

DOI: Digital Object Identifier

10.1021/acsnano.2c12233

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Languages

English

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