Outcomes with panobinostat in heavily pretreated multiple myeloma patients.

Author: CasasantaNicole, LeeAngela, MoshierErin, MouhieddineTarek H, PanDarren, RichterJoshua, UpadhyayRanjan, ZubizarretaNicole

Paper Details 
Original Abstract of the Article :
Panobinostat is an oral pan histone-deacetylase inhibitor used in the treatment of relapsed and refractory multiple myeloma. Previously published studies of panobinostat demonstrated synergy with bortezomib but included few patients exposed to newer agent combinations (ie, panobinostat plus daratumu...See full text at original site
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引用元:
https://doi.org/10.1053/j.seminoncol.2023.03.006

データ提供:米国国立医学図書館(NLM)

Panobinostat: A Hopeful Treatment for Multiple Myeloma

Multiple myeloma is a challenging type of blood cancer, and finding effective treatments for patients who have progressed beyond standard therapies is a constant struggle. This research explores the outcomes of panobinostat-based combinations in heavily pretreated multiple myeloma patients, providing valuable insights into the potential of this oral pan histone-deacetylase inhibitor.

A Glimpse of Hope in the Desert of Multiple Myeloma

The authors analyzed data from 105 patients with multiple myeloma treated with panobinostat, revealing modest response rates, particularly in patients with triple-class refractory disease. While the response rates were not overwhelming, the study provides evidence that panobinostat may offer a tolerable oral option for recapturing responses in patients with advanced disease.

Finding New Paths in Multiple Myeloma Treatment

This research, like a camel discovering a hidden spring in the desert, offers a glimmer of hope for patients with multiple myeloma. While panobinostat may not be a miracle cure, it shows promise as a potential treatment option for patients who have exhausted other therapies. It highlights the importance of continued research to develop new and effective treatments for this challenging disease.

Dr.Camel's Conclusion

This research provides valuable insights into the potential of panobinostat as a treatment option for patients with heavily pretreated multiple myeloma, particularly those with triple-class refractory disease. While the outcomes were modest, the study suggests that panobinostat may offer a tolerable oral option for recapturing responses in this challenging patient population. This research underscores the importance of exploring novel therapies and combinations to improve treatment outcomes for patients with multiple myeloma.

Date :
  1. Date Completed 2023-06-05
  2. Date Revised 2023-06-19
Further Info :

Pubmed ID

37005144

DOI: Digital Object Identifier

10.1053/j.seminoncol.2023.03.006

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SNS
PICO Info
in preparation
Languages

English

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