Patient-reported outcomes from the phase 3 ADMIRAL trial in patients with <i>FLT3</i>-mutated relapsed/refractory AML.

Author: CellaDavid, FabbianoFrancesco, IvanescuCristina, KandaYoshinobu, PandyaBhavik J, PigneuxArnaud, RitchieEllen K, ShahManasee V

Paper Details 
Original Abstract of the Article :
Patient-reported outcomes (PROs) can inform treatment selection and assess treatment value in acute myeloid leukemia (AML). We evaluated PROs from the ADMIRAL trial (NCT02421939) in patients with <i>FLT3</i>-mutated relapsed/refractory (R/R) AML. PRO instruments consisted of Brief Fatigue Inventory ...See full text at original site
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引用元:
https://doi.org/10.1080/10428194.2023.2186731

データ提供:米国国立医学図書館(NLM)

Gilteritinib: A Promising Treatment for FLT3-Mutated Relapsed/Refractory AML

The treatment of acute myeloid leukemia (AML), a type of blood cancer, is often challenging, especially in cases of relapsed/refractory disease. This study evaluates the patient-reported outcomes (PROs) of gilteritinib, a targeted therapy for FLT3-mutated AML, in patients enrolled in the ADMIRAL trial. The results indicate that gilteritinib effectively reduces fatigue and improves other PROs, including quality of life. The study also highlights the association between improved PROs and clinical outcomes, such as transplantation and transfusion independence. These findings suggest that gilteritinib offers a promising treatment option for patients with FLT3-mutated AML, potentially improving both clinical and quality-of-life outcomes.

Gilteritinib: A Potential Game-Changer for FLT3-Mutated AML

This research offers a beacon of hope for patients with FLT3-mutated AML, suggesting that gilteritinib could significantly improve both clinical and quality-of-life outcomes.

Gilteritinib: A Potential Game-Changer for FLT3-Mutated AML

Imagine AML as a fierce desert wind, disrupting the balance of the body's delicate ecosystem. Gilteritinib, like a sturdy sand dune, can potentially protect the ecosystem from the wind's harmful effects. This research highlights the potential of targeted therapies in effectively managing AML, potentially offering a chance for remission and improved quality of life.

Dr.Camel's Conclusion

This study demonstrates the remarkable potential of gilteritinib in treating FLT3-mutated AML. By effectively targeting this specific mutation, this drug offers a promising approach to improving both clinical and quality-of-life outcomes for patients with this challenging disease.

Date :
  1. Date Completed 2023-06-08
  2. Date Revised 2023-06-09
Further Info :

Pubmed ID

37019445

DOI: Digital Object Identifier

10.1080/10428194.2023.2186731

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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