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Effects of Ephedra Herb extract on the expression of EGFR-activating mutations and c-Met in non-small-cell lung cancer cell line, H1975, and its combined effects with osimertinib.
Author: HanawaToshihiko, HyugaSumiko, MoriEiko, NaokiKatsuhiko, OdaguchiHiroshi
Original Abstract of the Article :
We previously reported that the combined application of Ephedra Herb extract (EHE) and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), erlotinib, is effective in suppressing the growth of erlotinib-resistant non-small-cell lung cancer (NSCLC) cell line, H1993, xenograft tumo...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1007/s11418-023-01695-w
データ提供:米国国立医学図書館(NLM)
Ephedra Herb Extract: A Potential Ally in NSCLC Treatment
The field of [non-small-cell lung cancer (NSCLC)] treatment is constantly searching for new strategies to combat this challenging disease. This study investigates the potential therapeutic effects of [Ephedra Herb extract (EHE)] in combination with [osimertinib], a targeted therapy for NSCLC. The researchers explored the effects of EHE on [EGFR-activating mutations] and [c-Met] in NSCLC cells.
Ephedra Herb Extract: A Potential Ally in NSCLC Treatment
The study found that [EHE] effectively [downregulated the expression] of both [EGFR with activating mutations] and [c-Met], two key signaling pathways involved in NSCLC growth. The researchers observed a [concentration-dependent suppression] of NSCLC cell proliferation when EHE was used in combination with [osimertinib]. These findings suggest a potential synergistic effect between EHE and osimertinib in treating NSCLC.
Ephedra Herb Extract: A Potential Ally in NSCLC Treatment
This research provides a compelling rationale for further investigation into the potential of [EHE] as a [therapeutic adjuvant] for [NSCLC treatment]. The study's findings highlight the potential benefits of combining EHE with existing targeted therapies like [osimertinib]. Further clinical trials are needed to confirm the safety and efficacy of this combination therapy in treating NSCLC.
Dr. Camel's Conclusion
Just as camels rely on the resilience of desert plants to survive, we can harness the power of natural remedies like Ephedra Herb extract to combat the challenges of lung cancer. This study highlights the potential benefits of combining traditional remedies with modern therapies to develop more effective treatment strategies for NSCLC.
Date :
- Date Completed 2023-05-31
- Date Revised 2023-05-31
Further Info :
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