Sonidegib as a Locally Advanced Basal Cell Carcinoma Therapy in Real-life Clinical Setting: A National Multicentre Study.

Author: Bonfill-OrtíM, Béa-ArdebolS, DezaG, FealC, Fernández-de-MisaR, Ferrandiz-PulidoC, FlorezA, Galiano-MejíasS, Hernández-HernándezN, JakaA, MasferrerE, Mayo-MartinezF, Moreno-ArronesO M, Pérez-PastorG, Rios-BucetaL, Ruiz-SalasV, SanmartinO, TollA, Torres-NavarroI, Turrión-MerinoL, YébenesM

Paper Details 
Original Abstract of the Article :
BACKGROUND: Basal cell carcinoma (BCC) is the most prevalent cancer. A minority of BCCs have an aggressive behaviour (laBCC) and may require hedgehog pathway inhibitors such as sonidegib as its treatment. OBJECTIVE: To describe the use of sonidegib in a large number of patients and provide more dat...See full text at original site
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引用元:
https://doi.org/10.1016/j.ad.2023.04.022

データ提供:米国国立医学図書館(NLM)

Sonidegib: A New Weapon in the Battle Against Basal Cell Carcinoma

In the relentless fight against [basal cell carcinoma (BCC)], [hedgehog pathway inhibitors] have emerged as promising weapons. This study examines the effectiveness of [sonidegib], a hedgehog pathway inhibitor, in a real-world clinical setting. Imagine sonidegib as a sturdy camel, traversing the challenging desert landscape of BCC, seeking to restore balance and defeat the disease.

Sonidegib's Effectiveness in Real-World Clinical Practice

The study, conducted on a cohort of [82 patients], found that sonidegib showed impressive results. Over [81.7%] of patients experienced clinical improvement, with [52.4%] achieving partial response and [29.3%] achieving complete response. This is like seeing a barren desert landscape slowly bloom with life, a testament to sonidegib's effectiveness.

Sonidegib: A Promising Treatment Option with Acceptable Safety

While sonidegib demonstrated its effectiveness, it's important to note that [68.3%] of patients experienced at least one adverse effect, highlighting the need for careful monitoring and individualized treatment plans. Just as a camel must adapt to the harsh desert environment, patients must be carefully monitored for any potential side effects.

Dr. Camel's Conclusion

Sonidegib, like a strong and reliable camel, offers hope to patients battling BCC. Its real-world effectiveness is promising, but as with any treatment, a cautious and personalized approach is crucial. This study serves as a valuable guide, reminding us that the path to defeating BCC requires careful consideration and a collaborative approach between patients and their healthcare providers.

Date :
  1. Date Completed 2023-07-12
  2. Date Revised 2023-07-18
Further Info :

Pubmed ID

37088285

DOI: Digital Object Identifier

10.1016/j.ad.2023.04.022

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English

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