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Updates in the use of targeted therapies for the treatment of cholangiocarcinoma.

Author: LodlEmma, RamnaraignBrian, SahinIlyas, WheelerSarah

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review describes past and current treatment strategies for cholangiocarcinoma (CCA), with a focus on FDA-approved targeted therapies. Targeted therapies have significantly improved the prognosis for advanced or metastatic CCA.
Paper Details　
Original Abstract of the Article :
Many patients with cholangiocarcinoma (CCA) are not surgical candidates, and the survival benefit of chemotherapy is less than 12 months. Several mutations and mutational clusters have recently been identified in CCA, some of which are pharmacologically targetable. The emergence of targeted therapie...See full text at original site
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引用元：
https://doi.org/10.1177/10781552231171079

データ提供：米国国立医学図書館（NLM）

Targeted Therapies for Cholangiocarcinoma: A New Era of Treatment Options

This study explores the evolving landscape of cholangiocarcinoma (CCA) treatment, showcasing the emergence of targeted therapies as a powerful new approach to combatting this challenging disease. The researchers, like skilled archers aiming for precision, examine the latest advancements in targeted therapies for CCA, highlighting the potential to improve outcomes for patients who are not surgical candidates or who have experienced limited benefits from conventional chemotherapy.

The Power of Precision: Targeting Specific Mutations

The study emphasizes the importance of identifying specific mutations and mutational clusters in CCA, as these can be targeted by specific therapies. It's like a personalized approach to treatment, targeting specific weaknesses within the cancer cells. The researchers highlight the transformative impact of targeted therapies on the treatment landscape of CCA, offering hope for improved survival rates and a better quality of life for patients.

Dr. Camel's Conclusion

This review underscores the exciting advancements in targeted therapies for cholangiocarcinoma. It highlights the importance of personalized treatment approaches, tailored to the specific genetic and molecular characteristics of each patient's cancer. This research offers a beacon of hope for patients with CCA, paving the way for more effective and targeted treatments.

Date :
  1. Date Completed 2023-06-28
  2. Date Revised 2023-06-28
Further Info :

Pubmed ID

37097888

DOI: Digital Object Identifier

10.1177/10781552231171079

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Languages

English

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