Long-term effects of lumacaftor/ivacaftor on paranasal sinus abnormalities in children with cystic fibrosis detected with magnetic resonance imaging.

Author: AlrajabAbdulsattar, BaumannIngo, ChungJaehi, EichingerMonika, GraeberSimon Y, KauczorHans-Ulrich, MallMarcus A, SchenkJens-Peter, SeitzAngelika, SommerburgOlaf, StahlMirjam, WielpützMark O, WucherpfennigLena, WuennemannFelix, ZhaoShengkai

Paper Details 
Original Abstract of the Article :
<b>Introduction:</b> Chronic rhinosinusitis (CRS) usually presents with nasal congestion, rhinorrhea and anosmia impacts quality of life in cystic fibrosis (CF). Especially mucopyoceles pathognomonic for CRS in CF may cause complications such as spread of infection. Previous studies using magnetic ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123276/

データ提供:米国国立医学図書館(NLM)

Lumacaftor/Ivacaftor: A Hopeful Light in the Desert of Cystic Fibrosis

Cystic fibrosis (CF) is a complex and challenging condition, often leaving patients feeling like they're navigating a vast and unforgiving desert. This study focuses on the long-term effects of lumacaftor/ivacaftor, a promising treatment for CF, on paranasal sinus abnormalities, a common complication that can significantly impact quality of life. Researchers are like intrepid explorers, seeking to understand the impact of this medication on the long-term health of CF patients.

Their findings were encouraging, revealing that lumacaftor/ivacaftor therapy led to improvements in paranasal sinus abnormalities in children with CF who started treatment at school age. The medication appeared to prevent further deterioration in children who started treatment at preschool age. These results suggest that lumacaftor/ivacaftor could potentially prevent or reduce the progression of sinus complications, offering a glimmer of hope in the desert of CF.

A New Era in CF Treatment

This research adds to the growing body of evidence supporting the effectiveness of lumacaftor/ivacaftor in treating CF. The long-term benefits observed in this study, especially in preventing further deterioration of sinus abnormalities, offer a new era of hope for CF patients. It's like discovering a hidden oasis in the desert, a place of respite and rejuvenation for those struggling with this challenging condition.

A Collaborative Journey: Patients and Doctors

This research also highlights the importance of regular monitoring and a collaborative approach to CF treatment. Using magnetic resonance imaging (MRI) to monitor paranasal sinus abnormalities, doctors can tailor treatment plans to individual needs, ensuring that each patient receives the optimal care. It's a shared journey, with patients and doctors working together to navigate the complex landscape of CF, seeking out the best paths to better health and well-being.

Dr.Camel's Conclusion

This study offers a promising outlook for CF patients. Lumacaftor/ivacaftor appears to have a positive impact on paranasal sinus abnormalities, potentially preventing or reducing the progression of this complication. Remember, CF is a complex condition, and individual needs will vary. It's essential to work closely with your healthcare provider to develop a personalized treatment plan that addresses your unique needs and goals. Together, we can navigate the desert of CF, seeking out the oasis of better health and well-being.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-04-28
Further Info :

Pubmed ID

37101549

DOI: Digital Object Identifier

PMC10123276

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English

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