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A vein bypass first versus a best endovascular treatment first revascularisation strategy for patients with chronic limb threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal revascularisation procedure to restore limb perfusion (BASIL-2): an open-label, randomised, multicentre, phase 3 trial.

Author: , BateGareth R, BradburyAndrew W, ChetterIan, DeeksJonathan J, DiamantopoulosAthanasios, GaneshanArul, HallJack, HobbsSimon, HoulindKim, JarrettHugh, KellyLisa, LockyerSuzanne, MalmstedtJonas, MeechamLewis, MoakesCatherine A, PatelJai V, PatelSmitaa, PopplewellMatthew, RashidS Tawqeer, SaratzisAthanasios, ScottD Julian A, SlinnGemma, ZayedHany

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compares the effectiveness of vein bypass versus endovascular treatment for chronic limb-threatening ischemia. The study aims to determine which approach is more effective in preventing major amputation and death in patients requiring infra-popliteal revascularization.
Paper Details　
Original Abstract of the Article :
Chronic limb-threatening ischaemia is the severest manifestation of peripheral arterial disease and presents with ischaemic pain at rest or tissue loss (ulceration, gangrene, or both), or both. We compared the effectiveness of a vein bypass first with a best endovascular treatment first revascularis...See full text at original site
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引用元：
https://doi.org/10.1016/S0140-6736(23)00462-2

データ提供：米国国立医学図書館（NLM）

A Vein Bypass First Versus a Best Endovascular Treatment First Revascularisation Strategy for Patients with Chronic Limb Threatening Ischaemia who Required an Infra-popliteal, with or without an additional more proximal infra-inguinal revascularisation procedure to restore limb perfusion (BASIL-2): an open-label, randomised, multicentre, phase 3 trial

Chronic limb-threatening ischemia (CLTI), a severe manifestation of peripheral arterial disease, is like a desert storm, threatening to erode and destroy vital tissues. This study, published in [Journal Name], delves into the intricate world of revascularization procedures, investigating the effectiveness of two approaches for restoring blood flow to limbs affected by CLTI.

Comparing Revascularization Strategies in CLTI Treatment

This multi-center, phase 3 trial, like a well-planned expedition across a challenging desert, compared the effectiveness of two revascularization strategies in patients with CLTI: a vein bypass first approach and a best endovascular treatment first approach. The study aimed to determine which approach was more effective in preventing major amputation and death in patients who required an infra-popliteal revascularization procedure, with or without an additional more proximal infra-inguinal procedure.

Guiding Treatment Decisions for CLTI Patients

The results of the study, like a compass guiding a traveler through the desert, provide valuable information for clinicians who treat patients with CLTI. By carefully comparing the effectiveness of these two revascularization strategies, the study helps to inform treatment decisions, potentially improving outcomes for patients with this challenging condition.

Dr. Camel's Conclusion

This research offers a valuable roadmap for navigating the complexities of treating CLTI, providing clinicians with a better understanding of the effectiveness of different revascularization strategies. The study's results, like a shimmering oasis in the desert, offer hope for patients with CLTI, guiding clinicians towards more effective and personalized treatment approaches that improve their chances of preserving limb function and improving their quality of life.
Date :
  1. Date Completed 2023-05-29
  2. Date Revised 2023-05-31
Further Info :

Pubmed ID

37116524

DOI: Digital Object Identifier

10.1016/S0140-6736(23)00462-2

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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