[Pharmacological and clinical profile of asciminib hydrochloride, a novel first-in-class tyrosine kinase inhibitor specifically targeting ABL myristoyl pocket].

Author: AriyoshiTaisuke, ChungJihye, KagawaYusuke, KawakitaYasunori, MakiAkio, YonedaTomohiro

Paper Details 
Original Abstract of the Article :
On March 28th, 2022, asciminib hydrochloride (Scemblix<sup>&#174;</sup> Tablets 20&#8197;&#8205;mg/40&#8197;&#8205;mg), the world's first tyrosine kinase inhibitor (TKI) specifically targeting the ABL myristoyl pocket (STAMP inhibitor), was approved for chronic myeloid leukemia (CML) resistant or in...See full text at original site
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引用元:
https://doi.org/10.1254/fpj.22156

データ提供:米国国立医学図書館(NLM)

Asciminib: A New Treatment Option for Chronic Myeloid Leukemia

The field of

oncology

is continuously searching for new and effective treatments for

cancer

. This research focuses on a new drug called

asciminib

, a

tyrosine kinase inhibitor

specifically targeting the

ABL myristoyl pocket

. Asciminib has shown promise as a potential treatment for

chronic myeloid leukemia

(CML) patients who have limited options due to resistance or intolerance to prior therapies.

A New Weapon in the Fight Against CML

The study highlights the unique mechanism of action of asciminib and its effectiveness in inhibiting the growth of CML cells. The researchers conducted clinical trials to determine the optimal dosage and safety profile of asciminib. Their findings suggest that asciminib can be a valuable treatment option for patients with CML who have exhausted other therapies.

Hope on the Horizon for CML Patients

The development of new drugs like asciminib offers hope for patients with CML. By understanding the mechanisms of action and potential side effects of these drugs, oncologists can make more informed decisions about treatment, leading to improved outcomes for patients. Remember, just as a camel can navigate the desert with the help of a skilled guide, CML patients can benefit from the expertise of oncologists who use innovative treatments to guide their journey to recovery.

Dr.Camel's Conclusion

This research showcases the exciting progress being made in the development of new therapies for CML. Asciminib represents a promising new treatment option for patients with limited options. It's like discovering a hidden oasis in the desert – a place where hope and healing can flourish. The future of CML treatment is looking brighter than ever, thanks to ongoing research and development of innovative therapies like asciminib.

Date :
  1. Date Completed 2023-10-28
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

37121712

DOI: Digital Object Identifier

10.1254/fpj.22156

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Languages

Japanese

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