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Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis.

Author: AnDi, ChenXufeng, FanJunting, GaoRong, GeYaning, GeYingxin, HuangPeipei, JiangLei, WangJun, XuWeixiao, ZhangLinwei, ZhangZhongman, ZhuYi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Oxygen glucose deprivation (OGD) can trigger pyroptosis in human brain vascular pericytes (HBVPs), a process that is attenuated by the ketone compound bellidifolin.
Paper Details　
Original Abstract of the Article :
Pericytes play critical roles in the maintenance of brain vascular homeostasis. However, very little is currently known about how pericytes regulate ischemic stroke-induced brain injury. Inflammation is a key event in the pathobiology of stroke, in which the nod-like receptor protein-3 (NLRP3) infla...See full text at original site
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引用元：
https://doi.org/10.1007/s11064-023-03943-7

データ提供：米国国立医学図書館（NLM）

Brain Vascular Pericyte Injury: A Storm in the Desert

This study delves into the mechanisms of oxygen glucose deprivation (OGD)-induced human brain vascular pericyte injury, a critical event in the development of ischemic stroke. It's like experiencing a sudden storm in the desert, disrupting the delicate balance of the brain's vascular system.

Bellidifolin: A Protective Oasis

The study identified that bellidifolin, a compound derived from a traditional Tibetan medicinal plant, offers potential protection against OGD-induced pericyte injury by mitigating pyroptosis. It's like discovering a hidden oasis in the heart of the desert, providing shelter and restoration from the damaging effects of the storm.

Ischemic Stroke: A Journey Towards Recovery

This study highlights the potential of natural compounds in protecting against brain injury and offers a promising avenue for future research. It's a reminder that even in the face of devastating storms, there is always hope for finding a path towards recovery.

Dr.Camel's Conclusion

This research explores the intricate mechanisms of brain vascular pericyte injury and the potential of bellidifolin as a protective agent. It's a journey into the fascinating world of the brain, revealing potential solutions to a challenging medical problem. It's a reminder that even in the harshest deserts, there is always the possibility of finding a refuge, a source of strength, and a path towards healing.

Date :
  1. Date Completed 2023-07-21
  2. Date Revised 2023-07-21
Further Info :

Pubmed ID

37127800

DOI: Digital Object Identifier

10.1007/s11064-023-03943-7

SNS
PICO Info
in preparation
Languages

English

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