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Gilteritinib-induced severe immune-related enteritis: a possible case report.
Author: FanGuorong, GaoJunwei, LiuGaolin, LuoPan, QiuHuiying, SongXianmin, WuJiaqi, YangYushan
Original Abstract of the Article :
Gilteritinib is currently approved in China for relapsed/refractory FLT3-mutated acute myeloid leukemia, and it is very important to monitor and report its adverse drug reaction (ADR) after post-marketing. This case report describes a patient who was diagnosed with acute myeloid leukemia harboring F...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/37139936
データ提供:米国国立医学図書館(NLM)
Gilteritinib-Induced Severe Immune-Related Enteritis: A Case Report
The world of medicine is a vast desert of knowledge, and we're constantly searching for new oases of understanding. In this particular case, we're exploring the potential side effects of a medication called gilteritinib, which is used to treat a type of blood cancer called acute myeloid leukemia. This study, based on a single case report, delves into a severe complication that arose during treatment. The authors describe a patient who developed a severe case of enteritis, an inflammation of the intestines, while taking gilteritinib. This is a significant finding, as it highlights the importance of vigilant monitoring for potential adverse drug reactions, especially after a new medication enters the market.
A Possible Case of Adverse Drug Reaction
The authors categorized gilteritinib as a 'possible' cause of the enteritis based on the Naranjo probability scale. This means that while a causal link is suspected, more evidence is needed to definitively confirm it. The case also mentions a potential contribution from graft-versus-host disease, which can occur after a bone marrow transplant. However, this couldn't be ruled out definitively, making it a limitation of the study. Despite this, the report serves as a valuable warning sign for physicians and highlights the importance of closely monitoring patients for potential complications.
Navigating the Desert of Knowledge
This research sheds light on a potential adverse effect of gilteritinib, reminding us that even in the most advanced medical treatments, there are often uncharted territories. It is important to be aware of these potential risks and to be prepared to navigate the complexities of each individual case, just as we navigate the ever-shifting sands of the desert.
Dr.Camel's Conclusion
This case report serves as a reminder that even in the most promising treatments, there can be unexpected side effects. It's a valuable lesson in the ongoing search for new knowledge in the vast desert of medicine. Always remember to look out for the unexpected, and always be ready to adjust your course as new information emerges.
Date :
- Date Completed 2023-07-27
- Date Revised 2023-08-07
Further Info :
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