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Effects of elexacaftor/tezacaftor/ivacaftor therapy on mental health of patients with cystic fibrosis.

Author: GraeberSimon Y, LehmannChristine, MallMarcus A, PiehlerLinus, RöhmelJobst, StahlMirjam, SyunyaevaZulfiya, ThalemannRalf, TheeStephanie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Elexacaftor/tezacaftor/ivacaftor (ETI) is a CFTR modulator drug that improves CFTR function and symptoms in cystic fibrosis (CF) patients with at least one F508del allele. While some case reports suggest potential mental health side effects, a study of 70 adult CF patients with F508del showed that ETI improved depression symptoms without affecting anxiety.
Paper Details　
Original Abstract of the Article :
<b>Introduction:</b> The CFTR modulator drug elexacaftor/tezacaftor/ivacaftor (ETI) was shown to improve CFTR function and clinical symptoms in patients with cystic fibrosis (CF) with at least one <i>F508del</i> allele. Recently, some case reports suggested potential side effects of ETI on mental h...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160464/

データ提供：米国国立医学図書館（NLM）

Elexacaftor/Tezacaftor/Ivacaftor Therapy: A Look at Mental Health Impact

In the field of [cystic fibrosis (CF)] research, the development of [CFTR modulator drugs] like [elexacaftor/tezacaftor/ivacaftor (ETI)] has been a major breakthrough. This study investigates the potential impact of this triple combination therapy on the [mental health] of adult patients with [CF] who carry at least one [F508del allele]. The researchers conducted a prospective, observational study to examine the relationship between [ETI therapy initiation] and changes in mental health indicators.

ETI Therapy and Mental Health: Potential Benefits

The study's findings suggest that [ETI therapy initiation] may be associated with improvements in [depressive symptoms] in adult patients with [CF]. This research adds to the growing body of knowledge about the potential benefits and side effects of [ETI therapy], encouraging further exploration of its long-term impact on [mental health].

Supporting the Mental Well-being of CF Patients

This study highlights the importance of [proactive monitoring] for [mental health] in patients with [CF] undergoing [ETI therapy]. Understanding the potential impact of this therapy on [mental well-being] is crucial for providing appropriate support and interventions. Imagine a world where [CF patients] can receive the best possible care, both physically and mentally. The researchers' findings provide valuable insights to guide future research and clinical practice in this area.

Dr.Camel's Conclusion

This study reminds us that the desert of [CF] can be a challenging landscape, both physically and emotionally. Just as a camel relies on its reserves of water and strength to navigate the desert, patients with [CF] need ongoing support and care to thrive. This research provides valuable insights into the potential mental health impact of [ETI therapy] and inspires continued research in this area to ensure the well-being of individuals with [CF].

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-05-09
Further Info :

Pubmed ID

37153809

DOI: Digital Object Identifier

PMC10160464

SNS
PICO Info
in preparation
Languages

English

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