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Instrumental and transcriptome analysis reveals the chemotherapeutic effects of doxorubicin-loaded black phosphate nanosheets on abiraterone-resistant prostate cancer.

Author: DouTong, GaoLi, LaiKeng Po, LiJiawei, LiRong, LiXiangkai, LiZhuowei, LinXiao, LiuJiaqi, XuHaoyang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Abiraterone acetate is an effective treatment for prostate cancer, but resistance develops in 20-40% of patients. This study aimed to understand the mechanisms of abiraterone resistance and investigate the therapeutic potential of black phosphorus nanosheets (BPNS). BPNS reduced the proliferation and migration of abiraterone-resistant prostate cancer cells.
Paper Details　
Original Abstract of the Article :
Prostate cancer is the second most common cause of cancer-related deaths in men and is common in most developed countries. Androgen deprivation therapy (ADT) that uses abiraterone acetate (AA) is an effective second-line treatment for prostate cancer. However, approximately 20-40% of patients develo...See full text at original site
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引用元：
https://doi.org/10.1016/j.bioorg.2023.106583

データ提供：米国国立医学図書館（NLM）

Black Phosphorus Nanosheets: A Potential Weapon Against Resistant Prostate Cancer

Prostate cancer, a formidable foe in the battle against cancer, can sometimes develop resistance to standard treatments, leaving patients in a desert of therapeutic options. This study explores the potential of black phosphorus nanosheets (BPNS) as a chemotherapeutic agent for abiraterone-resistant prostate cancer. The researchers investigated the mechanisms underlying abiraterone resistance and evaluated the effects of BPNS on abiraterone-resistant prostate cancer cells.

BPNS: A Promising Approach to Resistances

The study found that [研究結果]. This finding suggests that [社会的な意義] and offers a potential new avenue for treating abiraterone-resistant prostate cancer.

Navigating the Challenges of Prostate Cancer

The research provides valuable insights for patients and clinicians managing prostate cancer. The study found that [研究結果]. It is important to discuss potential treatment options with a healthcare provider and to consider the role of emerging therapies, like BPNS, in overcoming drug resistance.

Dr.Camel's Conclusion

This study offers a ray of hope in the desert of prostate cancer treatment, highlighting the potential of BPNS as a promising therapeutic approach for overcoming abiraterone resistance. The research underscores the need for ongoing investigation into the mechanisms of drug resistance and the development of new and effective therapies to combat this challenging form of cancer.
Date :
  1. Date Completed 2023-06-15
  2. Date Revised 2023-06-16
Further Info :

Pubmed ID

37163810

DOI: Digital Object Identifier

10.1016/j.bioorg.2023.106583

Related Literature

Article Analysis
・Effects of abiraterone
SNS
PICO Info
in preparation
Languages

English

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