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A colloidal hydrogel-based drug delivery system overcomes the limitation of combining bisphosphonates with bioactive glasses: in vitro evidence of a potential selective bone cancer treatment allied with bone regeneration.

Author: BorgesRoger, JustoGiselle Zenker, MachadoJoel, MarchiJuliana, PelosineAgatha Maria, SchneiderJose Fabian, SouzaAna Carolina S, ZambaniniTelma, de AraujoDaniele R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This research proposes a novel hydrogel-based drug delivery system incorporating zoledronic acid (ZA) and holmium-doped bioactive glass nanoparticles to address the limitations of combining bisphosphonates with bioactive glasses for bone cancer treatment. This system effectively delivers ZA to osteosarcoma cells, demonstrating selective cell killing while promoting bone regeneration.
Paper Details　
Original Abstract of the Article :
Bisphosphonates are a class of drugs that induce bone cancer cell death and favor bone regeneration, making them suitable for bone cancer treatment. However, when combined with bioactive glasses to enhance bone regeneration, a chemical bond between biphosphonates and the glass surface inactivates th...See full text at original site
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引用元：
https://doi.org/10.1016/j.bioadv.2023.213441

データ提供：米国国立医学図書館（NLM）

A New Approach to Bone Cancer Treatment: A Colloidal Hydrogel-Based Delivery System

This research delves into the complex world of [bone cancer treatment] and explores a new approach using a [colloidal hydrogel-based drug delivery system]. The study focuses on the potential of [bisphosphonates], a class of drugs that induce [bone cancer cell death], in combination with [bioactive glasses] to enhance [bone regeneration]. However, the researchers discovered that a chemical bond forms between [bisphosphonates] and the glass surface, hindering the effectiveness of the treatment. This led them to develop a novel delivery system that overcomes this limitation.

A Double-Edged Sword: Bisphosphonates and Bioactive Glasses

The study explores the challenges of combining [bisphosphonates] and [bioactive glasses] in treating [bone cancer]. The researchers found that the chemical bond between the two components inhibits the effectiveness of the treatment. This is like a camel carrying a load of precious goods across the desert, but the goods are bound together, making it difficult for the camel to reach its destination.

Navigating the Challenges

This research proposes a new approach using a [colloidal hydrogel-based drug delivery system] to overcome the limitations of combining [bisphosphonates] and [bioactive glasses]. It offers a promising path towards a more effective treatment for [bone cancer].

Dr.Camel's Conclusion

This study explores the potential of a [colloidal hydrogel-based drug delivery system] to improve the effectiveness of [bisphosphonate] therapy in treating [bone cancer]. It offers a promising solution to the challenges of combining [bisphosphonates] with [bioactive glasses] and highlights the potential for a more targeted and effective treatment approach. Further research is needed to validate these findings and evaluate the long-term efficacy and safety of this innovative delivery system.
Date :
  1. Date Completed 2023-06-15
  2. Date Revised 2023-06-15
Further Info :

Pubmed ID

37167747

DOI: Digital Object Identifier

10.1016/j.bioadv.2023.213441

Related Literature

Article Analysis
・Effective treatment of bone cancer
SNS
PICO Info
in preparation
Languages

English

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