Paper Details

  1. Home
  2. Paper Details

The impact of metabolic stressors on mitochondrial homeostasis in a renal epithelial cell model of methylmalonic aciduria.

Author: BrutscheMarion, GroßOlaf, GrünertSarah C, HannibalLuciana, HavermansMonique, KölkerStefan, SchumannAnke, SpiekerkoetterUte

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Methylmalonic aciduria (MMA-uria), a metabolic disorder caused by methylmalonyl-CoA mutase (MUT) deficiency, is associated with a high risk of chronic kidney disease (CKD). This study investigates the effects of metabolic stressors on renal mitochondrial energy metabolism in MMA-uria patients, providing insights into the potential mechanisms leading to CKD development.
Paper Details　
Original Abstract of the Article :
Methylmalonic aciduria (MMA-uria) is caused by deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (MUT). MUT deficiency hampers energy generation from specific amino acids, odd-chain fatty acids and cholesterol. Chronic kidney disease (CKD) is a well-known long-term complication. We exp...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175303/

データ提供：米国国立医学図書館（NLM）

Metabolic Stressors and Mitochondrial Homeostasis in Methylmalonic Aciduria

This research delves into the complex world of [methylmalonic aciduria (MMA-uria)], a rare genetic disorder that affects [mitochondrial function] and can lead to [chronic kidney disease (CKD)]. The authors investigated the impact of [metabolic stressors] on [mitochondrial homeostasis] in [renal epithelial cells] from [MMA-uria patients], traversing the vast and intricate desert of [molecular biology] to understand the underlying mechanisms of this disease.

Metabolic Stressors Aggravate Mitochondrial Dysfunction

The study revealed that [metabolic stressors] such as [high protein intake] and [increased isoleucine/valine levels] further aggravated [mitochondrial dysfunction] in [MMA-uria cells]. These findings provide crucial insights into the [disease pathogenesis] and the potential for [complications] in [MMA-uria patients]. It's like a camel caravan encountering harsh desert conditions, where the already fragile ecosystem of [mitochondria] becomes even more vulnerable.

Understanding the Link Between MMA-uria and CKD

The research sheds light on the potential link between [MMA-uria] and [CKD]. The study found that [metabolic stressors] exacerbated [mitochondrial dysfunction] and [cellular damage] in [MMA-uria cells], providing a clearer understanding of the [disease progression] and the importance of [early intervention]. It's like understanding the intricate relationship between a desert ecosystem and the camels that traverse it, recognizing that certain conditions can lead to a decline in the health of both.

Dr. Camel's Conclusion

This research provides critical insights into the metabolic challenges faced by individuals with methylmalonic aciduria. Understanding the impact of metabolic stressors on mitochondrial homeostasis is crucial for developing effective therapies and preventing the development of chronic kidney disease in these patients.

Date :
  1. Date Completed 2023-05-15
  2. Date Revised 2023-06-01
Further Info :

Pubmed ID

37169781

DOI: Digital Object Identifier

PMC10175303

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.