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Acute and long-term effects of acetazolamide in presumed high loop gain sleep apnea.

Author: HolzerRena C, NiYue-Nan, ThomasRobert Joseph

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This retrospective analysis assessed the acute and long-term efficacy of acetazolamide (AZT) in patients with high loop gain sleep apnea (HLGSA). AZT significantly reduced residual sleep apnea both during positive pressure titration and over a 3-month period. Non-rapid eye movement (NREM) AHI3% was identified as a predictor of response to AZT. AZT was well-tolerated and beneficial for at least 3 months.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The acute effect during positive pressure titration and long term efficacy of acetazolamide (AZT) in high loop gain sleep apnea (HLGSA) is inadequately assessed. We predicted that AZT may improve HLGSA in both conditions. METHODS: A retrospective analysis of polysomnograms from patients...See full text at original site
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引用元：
https://doi.org/10.1016/j.sleep.2023.04.010

データ提供：米国国立医学図書館（NLM）

Acetazolamide: A Potential Solution for High Loop Gain Sleep Apnea

High loop gain sleep apnea (HLGSA) is a complex sleep disorder that can lead to significant daytime fatigue and other health problems. This research investigates the efficacy of acetazolamide, a medication typically used for other conditions, as a potential treatment for HLGSA. The study examines both the acute and long-term effects of acetazolamide in patients with presumed HLGSA.

Acetazolamide: A Refreshing Oasis in the Desert of Sleep Apnea

The study found that acetazolamide effectively reduced both the acute and chronic symptoms of HLGSA, improving both breathing-related arousals and apnea-hypopnea index (AHI). This suggests that acetazolamide may offer a valuable treatment option for patients with HLGSA, potentially improving their sleep quality and overall health. It's like discovering a hidden spring in the desert of sleep apnea, providing a source of relief and revitalization.

Finding Solace in the Desert of Sleep Apnea

This research underscores the importance of exploring innovative treatments for sleep disorders like HLGSA. While further research is needed to optimize the use of acetazolamide for HLGSA, it offers a promising path toward improving the lives of individuals struggling with this challenging condition. Like a camel seeking shade in the desert, those with HLGSA can find solace and support in the pursuit of effective treatments.

Dr. Camel's Conclusion

Acetazolamide emerges as a potential oasis in the desert of high loop gain sleep apnea, offering a source of relief and revitalization for those seeking a better night's sleep. This research highlights the importance of exploring new and innovative treatments for sleep disorders, bringing hope and support to those navigating the challenging landscape of sleep apnea.

Date :
  1. Date Completed 2023-06-16
  2. Date Revised 2023-06-19
Further Info :

Pubmed ID

37178545

DOI: Digital Object Identifier

10.1016/j.sleep.2023.04.010

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・Effects of acetazolamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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