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Population Pharmacokinetics of Posaconazole in Immune-Compromised Children and Assessment of Target Attainment in Invasive Fungal Disease.

Author: GarnerLauren M, GonzalezDaniel, McCannSean, McKinzieCameron J, SinhaJaydeep, WilsonWilliam S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study characterized the population pharmacokinetics (PK) of posaconazole (PSZ) in immunocompromised children. The study aimed to assess therapeutic target attainment using the oral suspension (OS) formulation, which is preferred for pediatric use.
Paper Details　
Original Abstract of the Article :
Posaconazole (PSZ) is a triazole antifungal for the management of invasive fungal disease (IFD) in adults and children. Although PSZ is available as an intravenous (IV) solution, oral suspension (OS) and delayed-release tablets (DRTs), OS is the preferred formulation for pediatric use because of pot...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/37179512

データ提供：米国国立医学図書館（NLM）

Posaconazole Pharmacokinetics in Children with Fungal Infections

This study investigates the pharmacokinetics of posaconazole (PSZ), an antifungal medication, in children with weakened immune systems who are battling invasive fungal infections. It's like exploring the intricate pathways of a desert river, where the flow of medicine needs to be precisely controlled to reach its destination. The study aimed to understand how PSZ is absorbed, distributed, metabolized, and eliminated in these children, optimizing treatment strategies.

Mapping the Desert of Posaconazole Pharmacokinetics

This study explores the pharmacokinetics of posaconazole (PSZ) in children with weakened immune systems, a group vulnerable to invasive fungal infections. The researchers conducted a population pharmacokinetic analysis to determine how PSZ behaves in these young patients, revealing the importance of optimizing drug delivery and dosage.

A Navigational Guide for Fungal Infections

This study provides crucial insights into the pharmacokinetics of PSZ in children, a valuable tool for healthcare providers in treating invasive fungal infections. It's like having a map to guide them through the desert of fungal infections, ensuring the delivery of effective treatment.

Dr. Camel's Conclusion

This research underscores the importance of understanding the pharmacokinetics of drugs, especially in vulnerable populations like children. It's like carefully studying the flow of water in a desert river, ensuring it reaches its destination without being lost in the sands. This study provides valuable data for optimizing PSZ treatment for children facing invasive fungal infections.
Date :
  1. Date Completed 2023-07-14
  2. Date Revised 2023-09-28
Further Info :

Pubmed ID

37179512

DOI: Digital Object Identifier

NIHMS1901131

Related Literature

Article Analysis
・Effects of posaconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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