Management of Gastro-Intestinal Toxicity of the Pi3 Kinase Inhibitor: Optimizing Future Dosing Strategies.

Author: BeuvonFrederic, BouscaryDidier, BrealClaire, ChouchanaLaurent, ContejeanAdrien, Deau-FisherBenedicte, DermineSolene, FaillieJean Luc, Franchi-RezguiPatricia, GrignanoEric, GuerinCorinne, TreluyerJean-Marc, VignonMarguerite, WillemsLise, de Witasse-ThezyThibault

Paper Details 
Original Abstract of the Article :
The phosphatidylinositol 3-kinase (PI3K) pathway plays a key role in cancer progression and in host immunity. Idelalisib was the first of this class to be approved with the second-generation Pi3 kinase inhibitors copanlisib, duvelisib and umbralisib, subsequently being approved in the United States....See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136502/

データ提供:米国国立医学図書館(NLM)

Managing Gastrointestinal Toxicity of Pi3 Kinase Inhibitors: A Guide for Optimal Dosing

The field of [oncology] is constantly evolving, with new therapies being developed to combat [cancer]. This review focuses on a class of drugs known as [Pi3 kinase inhibitors], which are proving to be effective in treating various [hematological malignancies]. The authors delve into the [gastrointestinal toxicity] associated with Pi3 kinase inhibitors, specifically focusing on [colitis]. The review provides a comprehensive overview of the available data on the incidence, management, and potential strategies to mitigate this adverse effect. This information is valuable for healthcare providers involved in the treatment of patients receiving Pi3 kinase inhibitors.

Optimizing Dosing Strategies for Pi3 Kinase Inhibitors

The review highlights the importance of [dosing strategies] in minimizing the [gastrointestinal toxicity] associated with Pi3 kinase inhibitors. The authors provide practical guidance for clinicians on managing [colitis] and suggest potential strategies to optimize dosing based on individual patient needs. This information is essential for maximizing the therapeutic benefits of Pi3 kinase inhibitors while minimizing adverse effects.

Health Implications and Lifestyle Applications

Individuals receiving Pi3 kinase inhibitors should be aware of the potential risk of [gastrointestinal toxicity], particularly [colitis]. Early detection and prompt management are key to minimizing complications. Patients should communicate any concerns about gastrointestinal symptoms to their healthcare providers to ensure appropriate treatment and monitoring. Further research is needed to develop safer and more tolerable Pi3 kinase inhibitors.

Dr.Camel's Conclusion

The journey to combat cancer is often paved with challenges, and the gastrointestinal toxicity of Pi3 kinase inhibitors is one such obstacle. This review provides a valuable guide for navigating this terrain, offering insights into managing colitis and optimizing dosing strategies. We eagerly await further research that may lead to safer and more effective Pi3 kinase inhibitors, ultimately improving the lives of patients battling cancer.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-05-19
Further Info :

Pubmed ID

37190206

DOI: Digital Object Identifier

PMC10136502

SNS
PICO Info
in preparation
Languages

English

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