Paper Details

  1. Home
  2. Paper Details

Evaluation of off-label rapamycin use to promote healthspan in 333 adults.

Author: AnJonathan Y, BlagosklonnyMikhail V, GreenAlan S, HaddadGeorge, HudsonJohnny, IsmanAnar, KaeberleinMatt, KaeberleinTammi L, NyquistAndy, RosenBradley S, SuhYousin, ZalzalaSajad, ZhangXingyu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Rapamycin is a medication that has been shown to extend lifespan in animals. This abstract describes a survey of 333 adults who have taken rapamycin off-label as a preventative therapy. The study found that rapamycin appears to be safe for adults with normal health.
Paper Details　
Original Abstract of the Article :
Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and healthspan metrics in yeast, invertebrates, and rodents. Several physicians are now prescribing rapamycin off-label as a preventat...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187519/

データ提供：米国国立医学図書館（NLM）

Rapamycin: A Potential Oasis in the Desert of Aging

The study of aging is a vast and complex desert, where scientists are continuously searching for ways to extend lifespan and improve healthspan. Rapamycin, an FDA-approved drug, has garnered attention for its potential to promote longevity and health. This study investigates the safety and potential benefits of off-label rapamycin use in healthy adults, seeking to uncover a potential oasis of extended healthspan in the desert of aging.

The authors collected data from a large cohort of adults who had been using rapamycin off-label for preventative purposes. The study found initial evidence that rapamycin can be used safely in adults with normal health status, offering a glimmer of hope in the desert of aging.

A Potential Fountain of Youth

The study's findings suggest that rapamycin may have the potential to contribute to a longer and healthier lifespan. This discovery could lead to new strategies for promoting healthy aging and combating age-related diseases.

A Glimpse of a Healthier Future

This research offers a glimmer of hope for a healthier future in the desert of aging. While more research is needed, the study's findings suggest that rapamycin may hold the key to unlocking a longer and healthier lifespan for individuals. This discovery reminds us that even in the seemingly endless expanse of the aging process, there may be hidden oases of potential waiting to be discovered.

Dr.Camel's Conclusion

The desert of aging is vast and often harsh, but rapamycin may be a glimmer of hope in the search for a longer and healthier life. This research offers a potential oasis in the desert of aging, reminding us that even in the face of inevitable decline, there are possibilities for extending healthspan.

Date :
  1. Date Completed 2023-11-15
  2. Date Revised 2023-11-16
Further Info :

Pubmed ID

37191826

DOI: Digital Object Identifier

PMC10187519

Related Literature

Article Analysis
・Side Effects of sirolimus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.