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Pharmacokinetics and immediate effects of high-dose carmustine in man.

Author: AntmanK, EderJ P, FreiE, HennerW D, PetersW P, SchnipperL

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

High-dose carmustine (BCNU) administration was associated with tachycardia, hypotension, flushing, confusion, nausea, and vomiting. Hypotension was a prominent feature of high-dose BCNU. The pharmacokinetic parameters for high-dose BCNU were similar to those reported for standard-dose BCNU.
Paper Details　
Original Abstract of the Article :
The pharmacokinetics and acute toxicity of carmustine (BCNU) have been studied in ten patients receiving high-dose combination chemotherapy with cyclophosphamide, cisplatin, and BCNU as treatment for advanced neoplasms. Patients received from 300 to 750 BCNU mg/m2 of body surface area as a 2-hour in...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3719578

データ提供：米国国立医学図書館（NLM）

High-Dose Carmustine: Understanding its Pharmacokinetics and Immediate Effects

Carmustine (BCNU) is a powerful chemotherapy drug often used to treat a range of cancers. This study delves into the pharmacokinetics and immediate effects of high-dose carmustine administration in patients receiving combination chemotherapy. The researchers carefully monitored the drug's levels in the blood and observed its immediate effects on patients. Their findings provide valuable insights into the drug's behavior in the body and highlight the importance of managing its potential side effects.

High-Dose Carmustine: A Powerful Tool with Potential Side Effects

The researchers found that high-dose carmustine administration led to various immediate effects, including tachycardia, hypotension, flushing, confusion, nausea, and vomiting. This knowledge helps clinicians anticipate and manage these side effects, optimizing patient care. The study also revealed key pharmacokinetic parameters of high-dose carmustine, providing a better understanding of its distribution, clearance, and protein binding in the body.

Navigating the Complexities of High-Dose Carmustine: A Guide for Healthcare Professionals

This study underscores the importance of understanding the pharmacokinetics and potential side effects of high-dose carmustine. By carefully monitoring patients and managing their side effects, healthcare professionals can ensure optimal outcomes for patients undergoing this type of chemotherapy. Like a camel navigating a challenging desert terrain, understanding the terrain and its potential hazards is crucial for successful navigation. This research provides valuable insights into the terrain of high-dose carmustine therapy, guiding safe and effective treatment.

Dr.Camel's Conclusion

This study provides important insights into the use of high-dose carmustine in cancer treatment. Understanding its pharmacokinetics and potential side effects helps clinicians make informed decisions regarding patient care. Remember, a wise camel knows its limits and navigates the desert with caution, just as healthcare professionals must carefully navigate the complexities of high-dose carmustine therapy.

Date :
  1. Date Completed 1986-08-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3719578

DOI: Digital Object Identifier

3719578

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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