Paper Details 
Original Abstract of the Article :
Analgesic effects of fentanyl have been investigated using behavior. The behavioral effects of fentanyl and possible serotonergic influence are largely unknown. We therefore investigated behavioral effects of fentanyl, with or without the serotonin antagonist ketanserin, in pigs. Fourteen mixed-bree...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215380/

データ提供:米国国立医学図書館(NLM)

Fentanyl's Unexpected Side Effects: A Journey Through the Desert of Pig Behavior

The desert of pain management research is vast and complex, with scientists constantly seeking to understand the effects of analgesics on various species. This study, published in 2023, explores the behavioral effects of fentanyl in healthy pigs. The researchers used a randomized, blinded, prospective study to investigate the effects of fentanyl on pig behavior, with and without the serotonin antagonist ketanserin. The study aims to shed light on the potential psychomotor side effects of fentanyl in pigs, a species often used in biomedical research.

Unmasking Fentanyl's Impact: Repetitive Behaviors and Stiff Gait

The study found that fentanyl induced various behavioral changes in pigs, including a decrease in resting and playing behaviors and an increase in repetitive behaviors. Fentanyl also caused a stiff gait pattern, suggesting potential motor impairment. The study's findings show that fentanyl can have significant psychomotor side effects in pigs, potentially interfering with pain assessment and post-operative recovery. The addition of ketanserin, a serotonin antagonist, reduced the duration of the stiff gait pattern, suggesting that serotonin may play a role in fentanyl's motor effects in pigs.

Navigating the Desert: Understanding the Implications of Fentanyl Use

This study highlights the importance of carefully considering the potential side effects of fentanyl in pigs, a species commonly used in biomedical research. The study's findings suggest that fentanyl can have significant psychomotor effects, potentially impacting pain assessment and recovery. This research provides valuable insights into the effects of fentanyl on pig behavior, emphasizing the need for careful monitoring and consideration of these side effects when using fentanyl in this species.

Dr. Camel's Conclusion

This study delves into the unexpected behavioral effects of fentanyl in pigs, a species often used in biomedical research. The study highlights the potential for fentanyl to induce psychomotor side effects, potentially affecting pain assessment and recovery. These findings underscore the importance of considering the behavioral consequences of fentanyl use in pigs and further highlight the complex interplay between pain management and behavioral effects in animals.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-05-30
Further Info :

Pubmed ID

37238100

DOI: Digital Object Identifier

PMC10215380

Related Literature

SNS
PICO Info
in preparation
Languages

English

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