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Targeting the EGFR signaling pathway in cancer therapy: What's new in 2023?

Author: BasuSoumi, BatraSurinder K, GantiApar K, HalderSushanta, LallShobhit P, SeshacharyuluParthasarathy

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This article provides an overview of epidermal growth factor receptor (EGFR) and its role in cancer development. EGFR is frequently amplified, overexpressed, and mutated in various cancers, leading to increased kinase activity that promotes uncontrolled proliferation and survival. The article describes the discovery and clinical efficacy of molecular agents targeting the EGFR pathway, highlighting the 14 currently approved EGFR-targeted agents for cancer treatment.
Paper Details　
Original Abstract of the Article :
Epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed, and mutated in multiple cancers. In normal cell physiology, EGFR signaling controls cellular differentiation, proliferation, growth, and survival. During tumorigenesis, mutations in EGFR lead to increased kinase activity...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/37243489

データ提供：米国国立医学図書館（NLM）

Targeting the EGFR Signaling Pathway: A New Oasis in the Desert of Cancer Treatment

Cancer, like a relentless sandstorm, can be a formidable foe. This research explores the role of the epidermal growth factor receptor (EGFR) signaling pathway in cancer and the development of targeted therapies to combat it. The researchers review the latest advancements in EGFR-targeted agents and their potential to revolutionize cancer treatment.

The Promise of EGFR-Targeted Therapies

The study highlights the potential of EGFR-targeted therapies to disrupt the growth and spread of cancer cells. These agents act like a precision weapon, targeting specific pathways involved in tumor development. The researchers note that 14 EGFR-targeted agents have been approved for cancer treatment, offering a glimmer of hope in the desert of cancer research.

Navigating the Desert of Cancer Research

The desert of cancer research is vast and complex, with ongoing efforts to find new and effective treatments. This research offers a glimpse into the promising world of EGFR-targeted therapies. It reminds us that the search for a cure for cancer is a continuous journey, with breakthroughs happening every day. The journey through the desert of cancer research is filled with both challenges and opportunities, and we must continue to explore every path toward a cure.

Dr.Camel's Conclusion

The research on EGFR-targeted therapies is like finding a new oasis in the desert of cancer treatment, offering hope for a more effective and targeted approach to fighting this disease. While there is still much to learn, this research provides valuable insights into the future of cancer treatment.

Date :
  1. Date Completed 2023-06-14
  2. Date Revised 2023-07-11
Further Info :

Pubmed ID

37243489

DOI: Digital Object Identifier

NIHMS1906261

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English

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