Patient-reported outcomes of maintenance rucaparib in patients with recurrent ovarian carcinoma in ARIEL3, a phase III, randomized, placebo-controlled trial.

Author: CellaDavid, ColemanRobert L, GobleSandra, IsaacsonJeff, LedermannJonathan A, PeipertJohn Devin, TangXiaodan, WallaceKatrine

Paper Details 
Original Abstract of the Article :
PURPOSE: To compare NFOSI-18 Disease Related Symptoms - Physical (DRSP), Total score, and side effect bother between maintenance rucaparib (600 mg twice daily) vs. placebo in the phase III ARIEL3 trial. METHODS: ARIEL3 (NCT01968213) included patients with ovarian carcinoma who responded to second-l...See full text at original site
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引用元:
https://doi.org/10.1016/j.ygyno.2023.05.060

データ提供:米国国立医学図書館(NLM)

The Impact of Rucaparib Maintenance Therapy on Patient-Reported Outcomes in Ovarian Carcinoma

The fight against ovarian carcinoma is a complex and challenging one, with researchers constantly searching for new treatments. This study dives into the world of PARP inhibitors and investigates the impact of rucaparib maintenance therapy on patient-reported outcomes. The researchers utilized a phase III, randomized, placebo-controlled trial called ARIEL3 to compare the effects of rucaparib to placebo in patients with recurrent ovarian carcinoma. The results revealed that rucaparib, while effective in some cases, also comes with side effects that can significantly impact patients' quality of life.

A Balancing Act: Benefits and Side Effects of Rucaparib

This study highlights the importance of balancing the potential benefits and side effects of cancer treatments. While rucaparib may offer valuable benefits in managing recurrent ovarian carcinoma, it can also lead to deterioration in patient-reported outcomes. This finding emphasizes the need for careful consideration and open communication between patients and their healthcare providers when weighing the potential benefits and risks of PARP inhibitor therapy.

Empowering Patients with Information

This study underscores the need for comprehensive patient education when considering PARP inhibitor therapy. Patients should be fully informed about the potential side effects and their impact on quality of life. This information empowers individuals to make informed decisions about their treatment options and allows them to work closely with their healthcare providers to manage any potential side effects. Imagine this process as a journey through a desert, where patients and providers navigate the landscape of treatment options together, finding the path that best meets their individual needs.

Dr.Camel's Conclusion

PARP inhibitors, while a promising addition to the arsenal against ovarian carcinoma, come with a complex set of side effects that must be carefully considered. This study provides valuable information for patients and their healthcare providers, empowering them to make informed decisions about treatment and manage potential side effects. The fight against cancer is a journey through a vast and often-uncharted desert, and this research helps illuminate a potential path forward, paving the way for more effective and personalized treatment strategies.

Date :
  1. Date Completed 2023-10-23
  2. Date Revised 2023-10-24
Further Info :

Pubmed ID

37262961

DOI: Digital Object Identifier

10.1016/j.ygyno.2023.05.060

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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