Early effects of acetazolamide on hemoglobin mass and plasma volume in chronic mountain sickness at 5100 m.

Author: BrugniauxJ V, ChampigneulleB, ConnesP, DoutreleauS, GuergourD, HanccoI, HoweC A, PichonA, PinaA, RobachP, Salazar-GranaraA A, StaufferE, VergesS

Paper Details 
Original Abstract of the Article :
Chronic Mountain Sickness (CMS) syndrome, combining excessive erythrocytosis and clinical symptoms in highlanders, remains a public health concern in high-altitude areas, especially in the Andes, with limited therapeutic approaches. The objectives of this study were to assess in CMS-highlanders perm...See full text at original site
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引用元:
https://doi.org/10.1016/j.pulmoe.2023.05.006

データ提供:米国国立医学図書館(NLM)

Acetazolamide: A Potential Treatment for Chronic Mountain Sickness

Chronic Mountain Sickness (CMS), a condition prevalent in highlanders, is a significant public health concern, particularly in the Andes region. This study investigates the early effects of acetazolamide (ACZ) and atorvastatin on hematocrit (Hct) levels and the underlying mechanisms in CMS-highlanders living in La Rinconada, Peru, the highest city in the world. The authors aimed to assess the efficacy of these drugs in reducing Hct and exploring the impact on intravascular volumes. This research contributes to the understanding of potential therapeutic approaches for CMS.

Acetazolamide: Early Efficacy in Reducing Hematocrit Levels

The study's findings indicate that acetazolamide shows early efficacy in reducing hematocrit levels in CMS-highlanders. This suggests that ACZ may be a promising treatment option for addressing the excessive erythrocytosis associated with CMS. Further research is needed to evaluate the long-term effects and optimize treatment strategies.

Chronic Mountain Sickness: Potential Treatment Options

This study sheds light on the potential of acetazolamide as a treatment option for Chronic Mountain Sickness. The early efficacy observed in this research provides a promising avenue for further investigation. This knowledge could lead to improved management strategies and better outcomes for individuals struggling with CMS.

Dr.Camel's Conclusion

The study's findings offer a glimmer of hope for those struggling with Chronic Mountain Sickness, like a rare desert flower blooming in the harsh environment. Acetazolamide, like a cool desert breeze, shows promise in reducing hematocrit levels and may offer a potential path to improved well-being for those living in high-altitude areas.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-06-01
Further Info :

Pubmed ID

37263861

DOI: Digital Object Identifier

10.1016/j.pulmoe.2023.05.006

Related Literature

SNS
PICO Info
in preparation
Languages

English

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