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Systolic time intervals in evaluation of the negative inotropic effect after single oral doses of mexiletine and disopyramide.

Author: BoisselJ P, FerryS, GalleyrandJ, PiolatC, RoussonD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Both mexiletine and disopyramide, at doses in the lower range of antiarrhythmic levels, had a negative inotropic effect, as measured by systolic time intervals. This effect was observed despite the low plasma levels of the drugs.
Paper Details　
Original Abstract of the Article :
A placebo-controlled, single blind, crossover study was done to evaluate the inotropic effects of single oral doses of mexiletine and disopyramide assessed by the measurement of Systolic Time Intervals (STI). Each of 8 healthy volunteers received five treatments in random order: 200 and 400 mg mexil...See full text at original site
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引用元：
https://doi.org/10.1007/BF00541525

データ提供：米国国立医学図書館（NLM）

Systolic Time Intervals in Evaluating the Negative Inotropic Effect of Mexiletine and Disopyramide

This study, like a careful desert expedition, investigates the negative inotropic effects of mexiletine and disopyramide, two medications used to treat heart rhythm problems. The study used Systolic Time Intervals (STI) to assess the impact of these medications on the heart's ability to contract. It's like using a compass to measure the strength of the heart's beat. The researchers found that both mexiletine and disopyramide had a negative inotropic effect, albeit at low plasma levels. This finding is like discovering a subtle change in the landscape of the heart's rhythm. The study emphasizes the importance of understanding the potential effects of these medications on the heart's function, highlighting the need for careful monitoring and personalized treatment approaches.

Negative Inotropic Effects: A Subtle Change in the Landscape of Heart Health

The study highlights the importance of understanding the subtle effects of medications on the heart's function. It's like realizing that even a small change in the desert's sand dunes can impact the overall landscape.

Living with Heart Rhythm Problems: Dr. Camel's Insights

Heart rhythm problems can be like a desert mirage, creating a sense of uncertainty and discomfort. It's essential to work closely with your doctor to find the right treatment approach. They'll help you navigate this challenging condition, like a trusted guide leading you through the desert.

Dr. Camel's Conclusion

This research provides valuable insights into the potential effects of mexiletine and disopyramide on the heart. It's like discovering a hidden spring in the desert of cardiovascular health. It's crucial to work closely with your doctor to ensure you receive the best possible care.

Date :
  1. Date Completed 1986-09-25
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

3732360

DOI: Digital Object Identifier

10.1007/BF00541525

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Languages

English

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