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Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5.
Author: BelyaevskayaSvetlana V, ClarkePenny, EgorovaAnna, EkinsSean, FrostJoshua, FuJianing, HurstBrett L, KazakovaElena, KloseThomas, KuhnRichard J, LaneThomas R, LeserJ Smith, MakarovVadim, RiabovaOlga, RudyMichael, SherryBarbara, TarbetBart, TylerKenneth L, VolobuevaAlexandrina S, ZarubaevVladimir V
Original Abstract of the Article :
Enteroviruses (EV) cause a number of life-threatening infectious diseases. EV-D68 is known to cause respiratory illness in children that can lead to acute flaccid myelitis. Coxsackievirus B5 (CVB5) is commonly associated with hand-foot-mouth disease. There is no antiviral treatment available for eit...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://pubmed.ncbi.nlm.nih.gov/37327878
データ提供：米国国立医学図書館（NLM）
A Novel Antiviral for Enteroviruses: Hope in the Desert of Infectious Disease
This research delves into the vast desert of infectious diseases, exploring the potential of a novel isoxazole-3-carboxamide analog of pleconaril (11526092) as a broad-spectrum antiviral for enteroviruses. The study, using mouse models of Enterovirus-D68 (EV-D68) and Coxsackievirus B5 (CVB5), demonstrated the potent in vitro and in vivo efficacy of 11526092 against these viruses. The researchers observed significant reductions in viral load and improved cytokine responses in infected mice, suggesting the potential of 11526092 as a promising antiviral therapeutic for EV-D68 and CVB5 infections.
A New Hope in the Fight Against Enteroviruses: 11526092
The study, like a camel discovering a hidden oasis in the desert of infectious disease, unveils the potential of 11526092 as a potent antiviral agent against enteroviruses. The researchers observed significant reductions in viral load and improved cytokine responses in infected mice, suggesting that 11526092 may offer a promising therapeutic option for treating EV-D68 and CVB5 infections. This finding provides a glimmer of hope in the ongoing battle against these debilitating viral infections.
Navigating the Desert of Enterovirus Infections with 11526092
This research offers valuable insights for navigating the desert of enterovirus infections. The study suggests that 11526092, a novel antiviral compound, may provide a valuable therapeutic option for treating EV-D68 and CVB5 infections. This groundbreaking research holds immense promise for developing effective treatments for these challenging viral infections.
Dr. Camel's Conclusion
This research, like a camel traversing a vast desert, reveals the potential of a novel isoxazole-3-carboxamide analog of pleconaril (11526092) as a potent antiviral agent against Enterovirus-D68 (EV-D68) and Coxsackievirus B5 (CVB5). The study's findings highlight the significant reductions in viral load and improved cytokine responses observed in infected mice, suggesting that 11526092 may offer a promising therapeutic option for treating these challenging viral infections. This groundbreaking research holds immense promise for developing effective treatments for these debilitating viral infections.
Date :
- Date Completed 2023-08-01
- Date Revised 2023-10-03
Further Info :
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