Paper Details

  1. Home
  2. Paper Details

Precision oncology with selective RET inhibitor selpercatinib in <i>RET</i>-rearranged cancers.

Author: GoudaMohamed A, SubbiahVivek

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article reviews the current status of selpercatinib, a selective RET inhibitor, for treating RET fusion-positive tumors. Selpercatinib has demonstrated efficacy in treating non-small cell lung cancer (NSCLC), thyroid cancers, and other RET-positive tumors.
Paper Details　
Original Abstract of the Article :
Rearranged during transfection (<i>RET</i>) is a protooncogene that encodes for receptor tyrosine kinase with downstream effects on multiple cellular pathways. Activating <i>RET alterations</i> can occur and lead to uncontrolled cellular proliferation as a hallmark of cancer development. Oncogenic <...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288430/

データ提供：米国国立医学図書館（NLM）

Precision Oncology: Targeting RET-Rearranged Cancers

The world of

cancer treatment

is rapidly evolving, with precision medicine offering new and targeted approaches to fight this complex disease. This article discusses the use of a selective RET inhibitor, selpercatinib, for treating cancers with RET gene rearrangements. RET is a gene that plays a role in cell growth and development. When this gene is altered, it can lead to uncontrolled cell growth and cancer. Selpercatinib specifically targets these altered RET genes, offering a promising treatment option for patients with RET-rearranged cancers.

Precision Medicine: Tailoring Treatment to Individual Needs

This article highlights the power of precision medicine in

cancer treatment

. By identifying the specific genetic alterations driving a patient’s cancer, we can develop targeted therapies that specifically attack these alterations, minimizing damage to healthy cells and improving treatment outcomes. This is like finding a specific oasis in a vast desert, where a traveler can quench their thirst and replenish their energy without having to navigate the entire desert. Precision medicine offers a personalized approach to

cancer treatment

, allowing us to target the specific needs of each patient.

The Future of Cancer Treatment: A Personalized Approach

The development of targeted therapies like selpercatinib represents a significant advancement in

cancer treatment

. This personalized approach holds tremendous promise for improving treatment outcomes and enhancing the lives of patients with RET-rearranged cancers. As we continue to explore the world of precision medicine, we are moving closer to a future where every patient receives the most effective and personalized treatment for their unique cancer journey.

Dr.Camel's Conclusion

The desert of

cancer treatment

is vast and unforgiving, but precision medicine is like a beacon of hope, guiding us towards more effective and personalized therapies. This article highlights the potential of selpercatinib, a targeted therapy that specifically attacks RET-rearranged cancers, offering new hope for patients who have been struggling with this disease. The future of

cancer treatment

is bright, as we continue to explore the power of precision medicine to personalize treatment and improve outcomes for all patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-18
Further Info :

Pubmed ID

37360768

DOI: Digital Object Identifier

PMC10288430

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.