Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout (<i>Oncorhynchus mykiss</i>) following Oral Administration.

Temperature's Influence on Doxycycline Pharmacokinetics in Rainbow Trout

The [pharmacokinetics] of [antibiotics] can be significantly influenced by environmental factors, such as [temperature]. This study explores the impact of temperature on the pharmacokinetics, tissue residues, and withdrawal times of [doxycycline] in [rainbow trout] following oral administration. The authors conducted a study comparing the pharmacokinetic behavior of doxycycline in rainbow trout reared at [10 °C] and [17 °C] following both single and multiple-day doses. Their findings demonstrate a significant impact of temperature on doxycycline pharmacokinetics, with higher temperatures resulting in faster elimination, increased peak plasma concentrations, and ultimately shorter withdrawal times. The study emphasizes the importance of considering temperature-dependent dosing regimens and withdrawal times for doxycycline in fish, ensuring optimal treatment efficacy and minimizing potential residues in edible tissues.

Temperature: A Key Regulator of Doxycycline Pharmacokinetics in Rainbow Trout

This study highlights the critical role of temperature in influencing the pharmacokinetics of doxycycline in rainbow trout. The authors demonstrate that higher temperatures lead to faster elimination, increased peak plasma concentrations, and ultimately shorter withdrawal times for this antibiotic. These findings underscore the importance of incorporating temperature-dependent dosing regimens and withdrawal periods for doxycycline in aquaculture practices, ensuring optimal treatment efficacy and minimizing potential residues in edible fish tissues.

Temperature-Sensitive Antibiotics: A Reminder for Aquaculture Practices

This research underscores the importance of considering temperature-dependent pharmacokinetics when using antibiotics in aquaculture practices. The authors' findings demonstrate that temperature significantly influences the pharmacokinetic behavior of doxycycline in rainbow trout, affecting its elimination rate, peak plasma concentrations, and withdrawal times. These findings highlight the need for a more nuanced approach to antibiotic use in aquaculture, ensuring optimal treatment efficacy and minimizing potential residues in edible fish tissues.

Dr. Camel's Conclusion

Just as a camel's body temperature fluctuates to navigate the extreme temperatures of the desert, the pharmacokinetics of antibiotics in fish can be significantly influenced by temperature. This study reveals the impact of temperature on doxycycline pharmacokinetics in rainbow trout, highlighting the need for temperature-dependent dosing regimens and withdrawal times in aquaculture practices. By understanding these temperature-sensitive relationships, we can ensure optimal treatment efficacy and minimize potential antibiotic residues in edible fish, contributing to the health of both fish and consumers.