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In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review.

Author: CanforaFederica, CelentanoAntonio, DuongTina D, GuirguisRobert H, HadiMohammad H, HasanAniqa, HicksRebecca M, HngJordan Y S, HuXia, MatthyssenTamara, McCulloughMichael, OwuamaHenry C, PaoliniRita, TanLeonard P

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Antiresorptive and antiangiogenic drugs were shown to have cytotoxic effects in a dose- and time-dependent manner in oral cells. These effects include decreases in cell proliferation, viability, and migration. Further research is required to fully understand the role of these drugs in the development of medication-related osteonecrosis of the jaw (MRONJ).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Invasive dental treatment in patients exposed to antiresorptive and antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ). Currently, the exact pathogenesis of this disease is unclear. METHODS: In March 2022, Medline (Ovid), Embase (Ovid), Scopus, and Web of...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296421/

データ提供：米国国立医学図書館（NLM）

Understanding the Complexities of MRONJ

This systematic review investigates the cellular mechanisms underlying medication-related osteonecrosis of the jaw (MRONJ), a challenging condition that can arise in patients taking antiresorptive and antiangiogenic drugs. This study is akin to a desert explorer meticulously mapping out the intricate pathways of a labyrinthine oasis.

Cellular Toxicity: Unraveling the Mechanisms of MRONJ

The review analyzed a multitude of studies examining the effects of antiresorptive and antiangiogenic drugs on oral cells. The results point towards a dose-dependent cytotoxicity, impacting cell proliferation, viability, and migration. This suggests that these drugs can disrupt the delicate balance of oral tissues, potentially leading to MRONJ.

Navigating the Desert of MRONJ

The insights from this study highlight the need for further research into the underlying mechanisms of MRONJ. Just as a desert nomad carefully navigates the treacherous dunes, healthcare professionals must understand the complexities of this condition to optimize treatment strategies and minimize risks.

Dr.Camel's Conclusion

This study reminds us that even the most well-intentioned medications can have unexpected consequences. It underscores the importance of ongoing research to understand the intricate mechanisms of drug action and to develop safer and more effective treatment options.
Date :
  1. Date Completed 2023-06-29
  2. Date Revised 2023-07-01
Further Info :

Pubmed ID

37371553

DOI: Digital Object Identifier

PMC10296421

Related Literature

Article Analysis
・Effective treatment of osteonecrosis
SNS
PICO Info
in preparation
Languages

English

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