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Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis.
Author: AsaadGihan F, El-DakrouryWalaa A, El-GizawySanaa A, ShabanaMarwa E, ZewailMoataz B
Original Abstract of the Article :
Rheumatoid arthritis (RA), a distressing inflammatory autoimmune disease, is managed mainly by Disease-modifying antirheumatic drugs (DMARDs), e.g. leflunomide (LEF). LEF (BCS class II) has limited solubility and adverse effects following its systemic exposure. The appealing antirheumatic properties...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.ijpharm.2023.123224
データ提供:米国国立医学図書館(NLM)
Chitosan-Coated Clove Oil Nanoemulsion: A New Oasis in the Desert of Rheumatoid Arthritis Treatment
This study explores a novel approach to delivering leflunomide, a medication used for rheumatoid arthritis (RA), using a chitosan-coated clove oil nanoemulsion. The researchers aimed to improve the efficacy and safety of leflunomide by enhancing its solubility and reducing systemic side effects.
A Multifaceted Approach to Rheumatoid Arthritis: Combining Natural and Pharmaceutical Solutions
The study demonstrated that the chitosan-coated clove oil nanoemulsion significantly reduced inflammation, improved motor function, and lowered liver enzyme levels in a rat model of RA. The results suggest that this approach may offer a more targeted and effective way to deliver leflunomide, minimizing its systemic side effects while maximizing its therapeutic benefits.
A New Frontier in Rheumatoid Arthritis Management: Combining Nature and Science
This research offers a promising avenue for treating rheumatoid arthritis, a debilitating condition that affects millions worldwide. The innovative approach of combining natural components with pharmaceutical formulations holds great potential for improving treatment outcomes and quality of life for patients with RA.
Dr.Camel's Conclusion
Just as a camel finds sustenance in the desert, this research seeks to deliver a potent therapeutic solution for rheumatoid arthritis. The chitosan-coated clove oil nanoemulsion offers a promising pathway to improve the delivery and efficacy of leflunomide, potentially revolutionizing the treatment of this challenging condition.
Date :
- Date Completed 2023-08-21
- Date Revised 2023-08-21
Further Info :
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