Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis.

Author: AsaadGihan F, El-DakrouryWalaa A, El-GizawySanaa A, ShabanaMarwa E, ZewailMoataz B

Paper Details 
Original Abstract of the Article :
Rheumatoid arthritis (RA), a distressing inflammatory autoimmune disease, is managed mainly by Disease-modifying antirheumatic drugs (DMARDs), e.g. leflunomide (LEF). LEF (BCS class II) has limited solubility and adverse effects following its systemic exposure. The appealing antirheumatic properties...See full text at original site
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引用元:
https://doi.org/10.1016/j.ijpharm.2023.123224

データ提供:米国国立医学図書館(NLM)

Chitosan-Coated Clove Oil Nanoemulsion: A New Oasis in the Desert of Rheumatoid Arthritis Treatment

This study explores a novel approach to delivering leflunomide, a medication used for rheumatoid arthritis (RA), using a chitosan-coated clove oil nanoemulsion. The researchers aimed to improve the efficacy and safety of leflunomide by enhancing its solubility and reducing systemic side effects.

A Multifaceted Approach to Rheumatoid Arthritis: Combining Natural and Pharmaceutical Solutions

The study demonstrated that the chitosan-coated clove oil nanoemulsion significantly reduced inflammation, improved motor function, and lowered liver enzyme levels in a rat model of RA. The results suggest that this approach may offer a more targeted and effective way to deliver leflunomide, minimizing its systemic side effects while maximizing its therapeutic benefits.

A New Frontier in Rheumatoid Arthritis Management: Combining Nature and Science

This research offers a promising avenue for treating rheumatoid arthritis, a debilitating condition that affects millions worldwide. The innovative approach of combining natural components with pharmaceutical formulations holds great potential for improving treatment outcomes and quality of life for patients with RA.

Dr.Camel's Conclusion

Just as a camel finds sustenance in the desert, this research seeks to deliver a potent therapeutic solution for rheumatoid arthritis. The chitosan-coated clove oil nanoemulsion offers a promising pathway to improve the delivery and efficacy of leflunomide, potentially revolutionizing the treatment of this challenging condition.

Date :
  1. Date Completed 2023-08-21
  2. Date Revised 2023-08-21
Further Info :

Pubmed ID

37451327

DOI: Digital Object Identifier

10.1016/j.ijpharm.2023.123224

Related Literature

SNS
PICO Info
in preparation
Languages

English

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